PD Dr. Mathias Schmelcher
PD Dr. Mathias Schmelcher
ZHAW
School of Life Sciences and Facility Management
Einsiedlerstrasse 31
8820 Wädenswil
Work at ZHAW
Position
Head of Molecular Biology and Biochemistry in co-leadership with Kerstin Gari
Focus
Enzyme-based antimicrobial agents
Teaching
Lecturer in Molecular Biology
Experience
- Private Lecturer
ETH Zurich
02 / 2021 - today - Senior Scientific Advisor
Micreos Pharmaceuticals
11 / 2023 - 05 / 2024 - Senior Assistant
ETH Zürich
04 / 2018 - 03 / 2024 - Chief Scientific Officer (CSO)
Micreos Pharmaceuticals
02 / 2022 - 11 / 2023 - Research Director
Micreos GmbH
01 / 2021 - 01 / 2022 - Postdoctoral Associate
ETH Zurich
04 / 2012 - 04 / 2018 - Research Molecular Biologist (Postdoctoral Associate)
United States Department of Agriculture (USDA)
01 / 2009 - 01 / 2012
Education and Continuing education
Education
- Doctor of Sciences
ETH Zurich
01 / 2004 - 04 / 2008 - Diploma in Biology
Technical University of Munich
09 / 1998 - 12 / 2003
Continuing Education
Habilitation (Venia Legendi in Microbiology)
ETH Zurich
09 / 2020
Network
ORCID digital identifier
Social media
Publications
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Roehrig, Christian; Huemer, Markus; Lorgé, Dominique; Arn, Fabienne; Heinrich, Nadine; Selvakumar, Lavanja; Gasser, Lynn; Hauswirth, Patrick; Chang, Chun-Chi; Schweizer, Tiziano A.; Eichenseher, Fritz; Lehmann, Steffi; Zinkernagel, Annelies S.; Schmelcher, Mathias,
2024.
mBio.
15(2), pp. e02540-23.
Available from: https://doi.org/10.1128/mbio.02540-23
Publications before appointment at the ZHAW
- MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections
- Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection
- CkP1 bacteriophage, a S16-like myovirus that recognizes Citrobacter koseri lipopolysaccharide through its long tail fibers
- Endolysin Inhibits Skin Colonization by Patient-Derived Staphylococcus Aureus and Malignant T-Cell Activation in Cutaneous T-Cell Lymphoma
- Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells
- A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging
- Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro, on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection
- Inflammatory Response of Primary Cultured Bovine Mammary Epithelial Cells to Staphylococcus aureus Extracellular Vesicles
- An Enzybiotic Regimen for the Treatment of Methicillin-Resistant Staphylococcus aureus Orthopaedic Device-Related Infection
- Fluorometric Paper-Based, Loop-Mediated Isothermal Amplification Devices for Quantitative Point-of-Care Detection of Methicillin-Resistant Staphylococcus aureus (MRSA)
- Deimmunization of protein therapeutics - Recent advances in experimental and computational epitope prediction and deletion
- In Situ Nucleic Acid Amplification and Ultrasensitive Colorimetric Readout in a Paper-Based Analytical Device Using Silver Nanoplates
- Bacteriophage endolysins - extending their application to tissues and the bloodstream
- Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic Staphylococcus aureus Infection
- Point-of-care testing system for digital single cell detection of MRSA directly from nasal swabs
- Glycotyping and Specific Separation of Listeria monocytogenes with a Novel Bacteriophage Protein Tool Kit
- Targeting Hidden Pathogens: Cell-Penetrating Enzybiotics Eradicate Intracellular Drug-Resistant Staphylococcus aureus
- Improved Biodistribution and Extended Serum Half-Life of a Bacteriophage Endolysin by Albumin Binding Domain Fusion
- Ultrasensitive and Fast Diagnostics of Viable Listeria Cells by CBD Magnetic Separation Combined with A511:: luxAB Detection
- Synergistic Removal of Static and Dynamic Staphylococcus aureus Biofilms by Combined Treatment with a Bacteriophage Endolysin and a Polysaccharide Depolymerase
- Tracing back multidrug-resistant bacteria in fresh herb production: from chive to source through the irrigation water chain
- Structural insights into the binding and catalytic mechanisms of the Listeria monocytogenes bacteriophage glycosyl hydrolase PlyP40
- Corrected and Republished from: Identification of Peptidoglycan Hydrolase Constructs with Synergistic Staphylolytic Activity in Cow's Milk
- Recombinant Endolysins as Potential Therapeutics against Antibiotic-Resistant Staphylococcus aureus: Current Status of Research and Novel Delivery Strategies
- Dynamics of culturable mesophilic bacterial communities of three fresh herbs and their production environment
- Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus
- Bacteriophage endolysins: applications for food safety
- Synergistic streptococcal phage λSA2 and B30 endolysins kill streptococci in cow milk and in a mouse model of mastitis
- Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection
- Biochemical and biophysical characterization of PlyGRCS, a bacteriophage endolysin active against methicillin-resistant Staphylococcus aureus
- Use of bacteriophage cell wall-binding proteins for rapid diagnostics of Listeria
- Application of bacteriophages for detection of foodborne pathogens
- Chimeric Ply187 endolysin kills Staphylococcus aureus more effectively than the parental enzyme
- Bacteriophage endolysins as novel antimicrobials
- Staphylococcus haemolyticus prophage ΦSH2 endolysin relies on cysteine, histidine-dependent amidohydrolases/peptidases activity for lysis 'from without'
- Staphylococcal phage 2638A endolysin is lytic for Staphylococcus aureus and harbors an inter-lytic-domain secondary translational start site
- Endolysins as antimicrobials
- Chimeric phage lysins act synergistically with lysostaphin to kill mastitis-causing Staphylococcus aureus in murine mammary glands
- Listeria bacteriophage peptidoglycan hydrolases feature high thermoresistance and reveal increased activity after divalent metal cation substitution
- Domain shuffling and module engineering of Listeria phage endolysins for enhanced lytic activity and binding affinity
- Rapid multiplex detection and differentiation of Listeria cells by use of fluorescent phage endolysin cell wall binding domains
- Comparative genome analysis of Listeria bacteriophages reveals extensive mosaicism, programmed translational frameshifting, and a novel prophage insertion site
- The high-affinity peptidoglycan binding domain of Pseudomonas phage endolysin KZ144
- Use of high-affinity cell wall-binding domains of bacteriophage endolysins for immobilization and separation of bacterial cells
- The crystal structure of the bacteriophage PSA endolysin reveals a unique fold responsible for specific recognition of Listeria cell walls
Other publications
- Patent application: WO/2023/166158 (2023), A chimeric endolysin polypeptide
- Patent application: WO/2023/166157 (2023), A chimeric endolysin polypeptide
- Patent application: WO/2023/166155 (2023), A chimeric endolysin polypeptide
- Patent application: WO/2021/213898 (2021), A chimeric endolysin polypeptide
- Patent application: WO/2014/039436 (2014), Staphylococcus haemolyticus prophage ΦSH2 endolysin is lytic for Staphylococcus aureus
- Patent application: WO/2010/020657 (2010), Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins
- Patent application: WO/2010/010192 (2010), New endolysin PlyP40