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Novel cell-based immunization technology and functional validation of resulting antibodies

Description

Development of a novel immunization method in rabbits that improves the generation of antibodies against the native form of human proteins e.g. cell surface receptors. Subsequent validation of the method through functional characterization of candidate therapeutic antibodies in vitro and in vivo. The aim is the discovery of monoclonal antibodies as novel therapeutics for two different first in class targets in cancer.

Key Data

Projectlead

Deputy Projectlead

Dr. Bruno Filippi

Co-Projectlead

Dr. Philippe Krebs, Prof. Dr. Frank Stenner

Project team

Bettina Keller Abu Seda, Jenny Pally, Leopold von Balthazar

Project partners

Memo Therapeutics AG

Project status

completed, 12/2017 - 11/2020

Funding partner

KTI-Projekt / Projekt Nr. 26019.2 PFLS-LS

Project budget

1'581'835 CHF