The HYKOM project demonstrates on a technical scale in the biogas plant of Klaus and Urs Wittwer the energetically and microbiologically optimized combination of hygienization, hydrolysis and anaerobic biogas production in the agricultural co-fermentation plant for liquid substrates. In a primary thermal treatment at 70 °C, hygienization, homogenization and thermal co-digestion are carried out.In a secondary anaerobic hydrolysis stage, the speed-limiting step of anaerobic degradation is carried out under the best possible conditions. The hydrolysis is operated continuously at a defined hydraulic retention time. The decoupling of "hygienization - hydrolysis - biogas production" stabilizes the plant operation and increases the substrate-specific biogas yield for certain substrates.