The simulation and optimization is predestined for high performance computing (HPC). Many computing operations are necessary and huge amounts of data are being generated. The requirements have also increased in recent years as the models become more complex. In addition, simulation-based optimization needs a large number of simulation runs, which should be parallelized if possible.However, the available approaches and products can only be used to a limited extent for these purposes, as there are restrictions on licenses and compatibility. As part of this project, we will explore and create the prerequisites and methods to use simulation and optimization on HPC. This in turn enables innovative research collaborations with industry.The start-up project is aimed at research and consolidation of knowledge and methods and the implementation of a feasibility and scalability study using a prototype. Methods and building blocks for a modular architecture for simulation-based optimization using HPC are developed and tested using the prototype.