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Catabolite Identification and Quantification

Description

Antibody-drug conjugates (ADC) are therapeutic monoclonal antibodies covalently conjugated to cytostatic agents featuring one of the new generation biopharmaceutical drugs for improved targeting of cancer cell killing. After receptor-mediated internalization of ADCs, the drugs are released and lead to cell death by interference with cellular structures. The goal of the project is the identification of the chemical nature of intracellular catabolites and the quantification thereof.

Key Data

Project status

ongoing, started 09/2023

Funding partner

Third party