Catabolite Identification and Quantification
Description
Antibody-drug conjugates (ADC) are therapeutic monoclonal antibodies covalently conjugated to cytostatic agents featuring one of the new generation biopharmaceutical drugs for improved targeting of cancer cell killing. After receptor-mediated internalization of ADCs, the drugs are released and lead to cell death by interference with cellular structures. The goal of the project is the identification of the chemical nature of intracellular catabolites and the quantification thereof.
Key Data
Projectlead
Project status
ongoing, started 09/2023
Institute/Centre
Institute of Chemistry and Biotechnology (ICBT)
Funding partner
Third party