Dr Kerstin Gari

Work at ZHAW

Position

Senior Lecturer in Biochemistry and Head Biochemistry Group

Focus

Cancer research; Isothermal DNA amplification methods

Teaching

Lecturer in Biochemistry

Experience

• SNSF Assistant Professor
  University of Zurich
  09 / 2013 - 03 / 2020
• Post-doctoral Fellow
  London Research Institute, UK
  01 / 2009 - 06 / 2013
• Post-doctoral Fellow
  University of Lausanne
  01 / 2008 - 12 / 2008

Education and Continuing education

Education

• PhD in Life Sciences / Biochemistry
  University of Lausanne
  06 / 2003 - 12 / 2007
• Diploma / Biology
  University of Heidelberg, Germany
  09 / 1997 - 12 / 2002
• Maîtrise / Cell Biology and Physiology
  University of Montpellier, France
  09 / 2000 - 06 / 2001

Continuing Education

CAS in Higher Education
PH Zurich
06 / 2022

Network

ORCID digital identifier

ORCID ID: 0000-0003-1276-8941

Projects

• A DNA repair protein as a target in cancer therapy / Project leader / abgeschlossen

Publications

• Lee, Wei Ting C.; Yin, Yandong; Morten, Michael J.; Tonzi, Peter; Gwo, Pam Pam; Odermatt, Diana C.; Modesti, Mauro; Cantor, Sharon B.; Gari, Kerstin; Huang, Tony T.; Rothenberg, Eli,

  2021.

  Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.

  Nature Communications.

  12(1), pp. 2525.

  Available from: https://doi.org/10.1038/s41467-021-22830-9

Publications before appointment at the ZHAW

• Mariotti, L., Wild, S., Brunoldi, G., Piceni, A., Ceppi, I., Kummer, S., Lutz, R.E., Cejka, P. & Gari, K. (2020) The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2. Commun Biol, 3, 322.
• Odermatt, D.C., Lee, W.T.C, Wild, S., Jozwiakowski S.K., Rothenberg, E. & Gari, K. (2020) Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism. PLOS Genetics, 16(6): e1008740.
• Simon, A.K., Kummer, S., Wild, S., Lezaja, A., Teloni, F., Jozwiakowski S.K., Altmeyer, M. & Gari, K. (2020) The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation. Life Sci Alliance, 3(3): e201900547.
• Porebski, B., Wild, S., Kummer, S., Scaglione, S., Gaillard, P.H.L. & Gari, K. (2019) WRNIP1 protects reversed DNA replication forks from SLX4-dependent nucleolytic cleavage. iScience 21, 31-41.
• Jozwiakowski, S.K., Kummer, S. & Gari, K. (2019) Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesis. Life Sci Alliance, 2: e201900321.
• Odermatt, D.C. & Gari, K. (2017) The CIA targeting complex is highly regulated and provides two distinct binding sites for client iron-sulfur proteins. Cell Reports, 18, 1434-1443.
• Lossaint, G., Larroque, M., Ribeyre, C., Bec, N., Larroque, C., Décaillet, C., Gari, K. & Constantinou, A. (2013) FANCD2 binds MCM proteins and controls replisome function upon activation of S phase checkpoint signaling. Mol Cell, 51, 678-90.
• Gari, K., León Ortiz, A.M., Borel, V., Flynn, H., Skehel, J.M. & Boulton, S.J. (2012) MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science 337, 243-5.
• Gari, K. & Constantinou, A. (2009) The role of the Fanconi anemia network in the response to DNA replication stress. Crit Rev Biochem Mol Biol, 44(5), 292-325.
• Gari, K., Décaillet, C., Delannoy, M., Wu, L. & Constantinou, A. (2008) Remodeling of DNA replication structures by the branchpoint translocase FANCM. PNAS, 105, 16107-12.
• Gari, K., Décaillet, C., Stasiak, A.Z., Stasiak, A. & Constantinou, A. (2008) The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell, 29, 141-8.
• Rehwinkel, J., Herold, A., Gari, K., Kocher, T., Rode, M., Ciccarelli, F.L., Wilm, M. & Izaurralde, E. (2004) Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol, 11, 558-66.

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