Burn Wound Treatment
This project is evaluating inhibitors of matrix metalloproteinase 9 (MMP-9) for the treatment of burn wounds. A specific molecule that reduces the production and activity of MMP-9 in certain cells is being studied.
Description
Matrix metalloproteinase 9 (MMP-9) plays a key role in many biological processes. While it is crucial for a normal immune response, excessive release of this enzyme can lead to severe tissue damage.
In this project, MMP inhibitors are being evaluated for the treatment of burn wounds. Here, a cyclic tissue inhibitor of metalloproteinase (TIMP) peptidomimetic, which downregulated MMP-9 expression both at the mRNA and protein levels as well as MMP-9 activity in THP-1-derived macrophages, is studied.
Key Data
Projectlead
Project team
Dr. Michael Brand, Flavio Gall
Project partners
Eidgenössische Materialprüfungs- und Forschungsanstalt EMPA
Project status
completed, 04/2020 - 09/2021
Institute/Centre
Institute of Chemistry and Biotechnology (ICBT)
Funding partner
Internal
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8820 Wädenswil