Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology
Description
Recently, GEA Westfalia Separator Group GmbH presented a single-use disc separator for microbial as well as mammalian cell culture processes. By using centrifugal force instead of filter-based harvesting methods, the GEA kytero® Single Use Pharma Separator is intended to achieve high-quality and high-yield separation results that are suitable for efficient up- or downscaling. As part of a joint research project, an evaluation is being carried out using an antibody-producing CHO cell line.
Key Data
Projectlead
Deputy Projectlead
Prof. Dr. Dieter Eibl
Project team
Project status
completed, 09/2021 - 06/2022
Funding partner
GEA Westfalia Separator Group GmbH
Publications
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Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production
2024 Ott, Vivian; Müller, Jan; Schirmer, Cedric; Weiss, Noémi; Göhmann, Rüdiger; Biewald, Andreas; Michel, Andrej; Eibl, Dieter; Eibl-Schindler, Regine
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Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale
2022 Schirmer, Cedric; Ott, Vivian; Müller, Jan; Göhmann, Rüdiger; Biewald, Andreas; Eibl-Schindler, Regine; Eibl, Dieter
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A new single-use disk stack separator for pilot scale CHO cell-based antibody productions
2022 Ott, Vivian; Müller, Jan; Eibl-Schindler, Regine; Eibl, Dieter; Schirmer, Cedric; Göhmann, Rüdiger; Biewald, Andreas