Infectious disease caused by bacteria constitutes a major threat to human health. Althoughantibiotics control bacterial infections, their efficacy is mitigated by the rise of antibioticresistance. Further challenging elimination of pathogenic bacteria, some species such asStaphylococcus aureus, responsible for a broad variety of infections, escape antibiotics bypersisting inside host cells. Here we will establish functionalized extracellular vesicles as anovel drug delivery system for target-specific, intracellular delivery of novel antimicrobialswith proven efficacy against S. aureus.