INCiTiS-FOOD (Integrated and Circular Technologies for Sustainable city region FOOD systems in Africa) is a 4-year project that aims to improve food and nutrition security (FNS) in African city regions and reduce the food-system-related environmental footprint while contributing to circularity. Furthermore, the project will empower communities by opening up opportunities for them in agri-food supply and value chains, and by achieving environmental justice through transformative food policies. This will be achieved through interdisciplinary research, integrated best-fit technologies, stakeholder led action, capacity-building, research-practitioner-policy collaborative engagement, and Europe-Africa partnership. The INCiTiS-FOOD project will co-create circular agri-food technologies, practices, and business models for an inclusive food system in African cities and towns. The agri-food technologies comprise soilless crop farming (hydroponics), recirculating aquaculture systems (RAS), and insect farming. These circular agri-food technologies have been deemed suitable for the context of African cities because they do not require great access to land, water, or wealth.The project is based on a multi-actor approach, involving 8 Living Labs (LLs) in 6 countries from 3 African regions (East: Kenya; West: Ghana, Nigeria, Sierra Leone; Central: Cameroon, Gabon). The INCiTiS-FOOD project will follow a Lean Start-up Methodology to achieve minimum viable products (MVPs). These MVPs are expected to reach a sufficiently high technological, societal, and business readiness level in 2 years into the 4-year project. The MVPs are further validated in a demonstration phase (800-1000+ start-ups and scalable small and medium-sized enterprises, SMEs) on the basis of 2 Open Calls for the Cascade Fund (FSTP: Financial Support to Third Parties). Beneficiaries of the Cascade Fund will be surveyed to generate empirical evidence on the co-benefits of the INCiTiS-FOOD project technologies and business models, which will guide urban food policy roadmaps for African cities.