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Real Time, Automation of Protien Evolution (RT-aPACE)

Real Time, Automated protien evolution (RT-aPACE) for the development of new gene editing tools (in partnership with University of Zurich (EvoFlow).

Description

This project aims to develop a real-time, automated system for evolving protein function. This will help to accelerate the development of high-precision gene editing tools for the therapeutic treatment of human disease. More specficially, the project will streamline the currently labour intensive worklfow associated with Phage Assisted Continuous Evolution, allowing rptiens to be evolved in a fully autonomous manner.

Key Data

Projectlead

Co-Projectlead

Dr. Lukas Schmidheini (Universität Zürich)

Project team

Project partners

Universität Zürich / Institut für Pharmakologie und Toxikologie (EvoFlow)

Project status

ongoing, started 04/2025

Institute/Centre

Institute of Mechatronic Systems (IMS)

Funding partner

Innosuisse Innovationsprojekt

Project budget

390'000 CHF