Novel cell-based immunization technology and functional validation of resulting antibodies
Description
Development of a novel immunization method in rabbits that improves the generation of antibodies against the native form of human proteins e.g. cell surface receptors. Subsequent validation of the method through functional characterization of candidate therapeutic antibodies in vitro and in vivo. The aim is the discovery of monoclonal antibodies as novel therapeutics for two different first in class targets in cancer.
Key Data
Projectlead
Deputy Projectlead
Dr. Bruno Filippi
Co-Projectlead
Dr. Philippe Krebs, Prof. Dr. Frank Stenner
Project team
Bettina Keller Abu Seda, Jenny Pally, Leopold von Balthazar
Project partners
Memo Therapeutics AG
Project status
completed, 12/2017 - 11/2020
Funding partner
KTI-Projekt / Projekt Nr. 26019.2 PFLS-LS
Project budget
1'581'835 CHF