Zebrafish larvae for drug screening
At a glance
- Project leader : Prof. Dr. Lars Fieseler, Prof. Dr. Steffi Lehmann, Mathias Sigrist
- Deputy of project leader : Boris Pasini, Dr. Marjan Veljkovic
- Project team : Patrick Erpen, Laila Mara Müller, Nathalie Pfister, Fridolin Tschudi
- Project status : ongoing
- Funding partner : Other
- Contact person : Steffi Lehmann
Description
Inthis 3RCC-funded project, we aim to reduce the number of rodents employed forthe screening of novel antimicrobials using a zebrafish larval model ofbacterial infections. We will set up live microscopic imaging readouts tomonitor bacterial spread in zebrafishlarvae and will use the model to screen novel, bacteriophage-derivedantimicrobials regarding efficacy. This will allow to select drug candidatesfor further preclinical development in zebrafish larvae rather than rodents,thereby significantly reducing the number of mice normally used for thispurpose.