Prof. Dr. Ing. Regine Eibl-Schindler

ZHAW School of Life Sciences and Facility Management
Center for Cell Cultivation Techniques, Tissue Engineering and Medical Biology
Grüentalstrasse 14
8820 Wädenswil

+41 (0) 58 934 57 13
regine.eibl@zhaw.ch

Projects

USP development with CHO cells / Project leader / abgeschlossen
A platform enabling efficient and effective delivery and packaging of therapeutic molecules / Co-project leader / abgeschlossen

Publications

Articles in scientific journal, peer-reviewed

Ott, Vivian; Ott, Jan; Eibl, Dieter; Eibl-Schindler, Regine,

2024.

Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors.

Processes.

12(4), pp. 806.

Available from: https://doi.org/10.3390/pr12040806
Ott, Jan; Ott, Vivian; Neubauer, Peter; Eibl, Dieter; Eibl-Schindler, Regine,

2024.

Process intensification by inoculating antibody production bioreactors directly from cryovials .

Chemie Ingenieur Technik.

96(4), pp. 453-461.

Available from: https://doi.org/10.1002/cite.202300189
Teale, Misha Alexander; Schneider, Samuel Lukas; Eibl, Dieter; Eibl-Schindler, Regine,

2024.

Process intensification in human pluripotent stem cell expansion with microcarriers.

Processes.

12(3), pp. 426.

Available from: https://doi.org/10.3390/pr12030426
Seidel, Stefan; Mozaffari, Fruhar; Maschke, Rüdiger W.; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter,

2023.

Automated shape and process parameter optimization for scaling up geometrically non-similar bioreactors.

Processes.

11(9), pp. 2703.

Available from: https://doi.org/10.3390/pr11092703
Teale, Misha A.; Schneider, Samuel; Eibl, Dieter; van den Bos, Christian; Neubauer, Peter; Eibl, Regine,

2023.

Mesenchymal and induced pluripotent stem cell-based therapeutics : a comparison.

Applied Microbiology and Biotechnology.

107(14), pp. 4429-4445.

Available from: https://doi.org/10.1007/s00253-023-12583-4
Seidel, Stefan; Maschke, Rüdiger; Mozaffari, Fruhar; Eibl-Schindler, Regine; Eibl, Dieter,

2023.

Improvement of HEK293 cell growth by adapting hydrodynamic stress and predicting cell aggregate size distribution.

Bioengineering.

10(4), pp. 478.

Available from: https://doi.org/10.3390/bioengineering10040478
Seidel, Stefan; Eibl-Schindler, Regine; Eibl, Dieter,

2022.

Laboratory-independent exploration of stirred bioreactors and their fluid dynamics.

Education for Chemical Engineers.

42, pp. 80-87.

Available from: https://doi.org/10.1016/j.ece.2022.10.001
Seidel, Stefan; Maschke, Rüdiger; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter,

2022.

CFD modelling of a wave-mixed bioreactor with complex geometry and two degrees of freedom motion.

Frontiers in Chemical Engineering.

4(1021416).

Available from: https://doi.org/10.3389/fceng.2022.1021416
Müller, Jan; Ott, Vivian; Weiss, Noémi; Neubauer, Peter; Eibl, Dieter; Eibl, Regine,

2022.

Process intensification using a one‐step inoculum production and high‐seeded fed‐batch processes.

Chemie Ingenieur Technik.

94(12), pp. 1977-1984.

Available from: https://doi.org/10.1002/cite.202200097
Maschke, Rüdiger W.; Seidel, Stefan; Bley, Thomas; Eibl, Regine; Eibl, Dieter,

2022.

Determination of culture design spaces in shaken disposable cultivation systems for CHO suspension cell cultures.

Biochemical Engineering Journal.

177, pp. 108224.

Available from: https://doi.org/10.1016/j.bej.2021.108224
Ott, Vivian; Müller, Jan; Schirmer, Cedric; Weiss, Noémi; Göhmann, Rüdiger; Biewald, Andreas; Michel, Andrej; Eibl, Dieter; Eibl-Schindler, Regine,

2022.

Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production.

Chemie Ingenieur Technik.

94(12), pp. 1936-1943.

Available from: https://doi.org/10.1002/cite.202200096
Müller, Jan; Ott, Vivian; Eibl, Dieter; Eibl-Schindler, Regine,

2022.

Seed train intensification using an ultra-high cell density cell banking process.

Processes.

10(5), pp. 911.

Available from: https://doi.org/10.3390/pr10050911
Schirmer, Cedric; Eibl-Schindler, Regine; Maschke, Rüdiger; Mozaffari, Fruhar; Junne, Stefan; Daumke, Ralph; Ottinger, Melanie; Göhmann, Rüdiger; Ott, Christian; Wenk, Irina; Kubischik, Jens; Eibl, Dieter,

2022.

Single‐use technology for the production of cellular agricultural products : where are we today?.

Chemie Ingenieur Technik.

94(12), pp. 2018-2025.

Available from: https://doi.org/10.1002/cite.202200092
Muoio, Francesco; Panella, Stefano; Lindner, Matias; Jossen, Valentin; Harder, Yves; Moccetti, Tiziano; Eibl-Schindler, Regine; Müller, Michele; Tallone, Tiziano,

2021.

Development of a biodegradable microcarrier for the cultivation of human adipose stem cells (hASCs) with a defined xeno- and serum-free medium.

Applied Sciences.

11(3), pp. 925.

Available from: https://doi.org/10.3390/app11030925
Eibl, Regine; Senn, Yannick; Gubser, Géraldine; Jossen, Valentin; van den Bos, Christian; Eibl, Dieter,

2021.

Cellular agriculture : opportunities and challenges.

Annual Review of Food Science and Technology.

12, pp. 51-73.

Available from: https://doi.org/10.1146/annurev-food-063020-123940
Panella, Stefano; Muoio, Francesco; Jossen, Valentin; Harder, Yves; Eibl-Schindler, Regine; Tallone, Tiziano,

2021.

Chemically defined xeno- and serum-free cell culture medium to grow human adipose stem cells.

Cells.

10(2), pp. 466.

Available from: https://doi.org/10.3390/cells10020466
Gubser, Geraldine; Vollenweider, Sabine; Eibl, Dieter; Eibl, Regine,

2021.

Food ingredients and food made with plant cell and tissue cultures : state‐of‐the art and future trends.

Engineering in Life Sciences.

21(3-4), pp. 87-98.

Available from: https://doi.org/10.1002/elsc.202000077
Muoio, Francesco; Panella, Stefano; Jossen, Valentin; Lindner, Matias; Harder, Yves; Müller, Michele; Eibl, Regine; Tallone, Tiziano,

2021.

Human adipose stem cells (hASCs) grown on biodegradable microcarriers in serum- and xeno-free medium preserve their undifferentiated status.

Journal of Functional Biomaterials.

12(2), pp. 25.

Available from: https://doi.org/10.3390/jfb12020025
Eibl, Dieter; Sievers, Martin; Eibl, Regine; Bachmann, Martin; Walton, Senta; Keel, Nik; Richner, Gilles; Stübinger, Stefan; Hirsch, Sven; Yeretzian, Chahan; Opitz, Sebastian E.W.; Heldal, Trond; Adlhart, Christian,

2021.

Keeping SARS-CoV-2 out : vaccines, filters, and self-disinfecting textiles.

Chimia.

75(3), pp. 215-218.

Available from: https://doi.org/10.2533/chimia.2021.215
Jossen, Valentin; Muoio, Francesco; Panella, Stefano; Harder, Yves; Tallone, Tiziano; Eibl-Schindler, Regine,

2020.

An approach towards a GMP compliant in-vitro expansion of human adipose stem cells for autologous therapies.

Bioengineering.

7(3), pp. 77.

Available from: https://doi.org/10.3390/bioengineering7030077
Khojasteh, Abbas; Mirjalili, Mohammad Hossein; Alcalde, Miguel Angel; Cusido, Rosa M.; Eibl, Regine; Palazon, Javier,

2020.

Powerful plant antioxidants : a new biosustainable approach to the production of rosmarinic acid.

Antioxidants.

9(12), pp. 1273.

Available from: https://doi.org/10.3390/antiox9121273
Möller, Johannes; Hernández Rodríguez, Tanja; Müller, Jan; Arndt, Lukas; Kuchemüller, Kim B.; Frahm, Björn; Eibl-Schindler, Regine; Eibl, Dieter; Pörtner, Ralf,

2019.

Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes.

Computers & Chemical Engineering.

134, pp. 106693.

Available from: https://doi.org/10.1016/j.compchemeng.2019.106693
Khojasteh, Abbas; Sanchez-Munoz, Raul; Moyano, Elisabeth; Bonfill, Mercedes; Cusido, Rosa M.; Eibl, Regine; Palazon, Javier,

2019.

Biotechnological production of ruscogenins in plant cell and organ cultures of Rescus aculeatus.

Plant Physiology and Biochemistry.

141, pp. 133-141.

Available from: https://doi.org/10.1016/j.plaphy.2019.05.029
Khojasteh, Abbas; Metón, Isidoro; Camino, Sergio; Cusido, Rosa M.; Eibl-Schindler, Regine; Palazon, Javier,

2019.

In vitro study of the anticancer effects of biotechnological extracts of the endangered plant species satureja khuzistanica.

International Journal of Molecular Sciences.

20(10), pp. 2400.

Available from: https://doi.org/10.3390/ijms20102400
Jossen, Valentin; Eibl-Schindler, Regine; Kraume, Matthias; Eibl, Dieter,

2018.

Growth behavior of human adipose tissue-derived stromal/stem cells at small scale : numerical and experimental investigations.

Bioengineering.

5(4), pp. 106.

Available from: https://doi.org/10.3390/bioengineering5040106
Eibl-Schindler, Regine; Jossen, Valentin; Eibl, Dieter,

2018.

Einweg-Bioreaktoren : therapeutische Antikörper.

Chemie in unserer Zeit.

52(4), pp. 230-237.

Available from: https://doi.org/10.1002/ciuz.201800803
Jossen, Valentin; van den Bos, Christian; Eibl-Schindler, Regine; Eibl, Dieter,

2018.

Manufacturing human mesenchymal stem cells at clinical scale : process and regulatory challenges.

Applied Microbiology and Biotechnology.

102(9), pp. 3981-3994.

Available from: https://doi.org/10.1007/s00253-018-8912-x
Eibl-Schindler, Regine; Meier, Philipp; Stutz, Irène Kathrin; Schildberger, David; Hühn, Tilo; Eibl, Dieter,

2018.

Plant cell culture technology in the cosmetics and food industries : current state and future trends.

Applied Microbiology and Biotechnology.

102(20), pp. 8661-8675.

Available from: https://doi.org/10.1007/s00253-018-9279-8
Schirmer, Cedric; Blaschczok, Katharina; Husemann, Ute; Leupold, Marco; Zahnow, Christian; Rupprecht, Jens; Glöckler, Rainer; Greller, Gerhard; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter,

2017.

Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes.

Chemie Ingenieur Technik.

89(12).

Available from: https://doi.org/10.1002/cite.201700039
Eibl, Dieter; Eibl-Schindler, Regine,

2017.

Flexible biomanufacturing for the production of biotherapeutics.

Pharmaceutical Biomanufacturing.

5(1).
Demuth, Caspar; Varonier, Joel; Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

2016.

Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale.

Applied Microbiology and Biotechnology.

100(9), pp. 3853-3863.

Available from: https://doi.org/10.1007/s00253-016-7412-0
Khojasteh, Abbas; Mirjalili, Mohammad Hossein; Palazon, Javier; Eibl-Schindler, Regine; Cusido, Rosa M.,

2016.

Methyl jasmonate enhanced production of rosmarinic acid in cell cultures of Satureja khuzistanica in a bioreactor.

Engineering in Life Sciences.

16(8), pp. 740-749.

Available from: https://doi.org/10.1002/elsc.201600064
Jossen, Valentin; Schirmer, Cedric; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

2016.

Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes.

Stem Cells International.

2016(4760414).

Available from: https://doi.org/10.1155/2016/4760414
Imseng, Nicole; Steiger, Nina; Frasson, David; Sievers, Martin; Tappe, Alexander; Greller, Gerhard; Eibl, Dieter; Eibl-Schindler, Regine,

2014.

Single-use wave-mixed versus stirred bioreactors for insect-cell/BEVS-based protein expression at benchtop scale.

Engineering in Life Sciences.

14(3), pp. 264-271.

Available from: https://doi.org/10.1002/elsc.201300131
Blaschczok, Katharina; Löffelholz, Christian; Eibl-Schindler, Regine; Eibl, Dieter,

2014.

Combining single-use stirred bioreactor with standard cross-flow technology in biphasic protein production processes at pilot scale.

Engineering in Life Sciences.

14(3), pp. 327-331.

Available from: https://doi.org/10.1002/elsc.201300069
Schirmaier, Carmen; Jossen, Valentin; Kaiser, Stephan C.; Jüngerkeks, Frank; Silke, Brill; Safavi-Nab, Agnieszka; Siehoff, Ann; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

2014.

Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions.

Engineering in Life Sciences.

14(3), pp. 292-303.

Available from: https://doi.org/10.1002/elsc.201300134
Vasilev, Nikolay; Schmitz, Christian; Dong, Lemeng; Ritala, Anneli; Imseng, Nicole; Häkkinen, Suvi T.; van der Krol, Sander; Eibl-Schindler, Regine; Oksman-Caldentey, Kirsi-Marja; Bouwmeester, Harro; Fischer, Rainer; Schillberg, Stefan,

2014.

Comparison of plant-based expression platforms for the heterologous production of geraniol.

Plant Cell, Tissue and Organ Culture (PCTOC).

117(3), pp. 373-380.

Available from: https://doi.org/10.1007/s11240-014-0446-z
Ritala, Anneli; Dong, Lemeng; Imseng, Nicole; Seppänen-Laakso, Tuulikki; Vasilev, Nikolay; van der Krol, Sander; Rischer, Heiko; Maaheimo, Hannu; Virkki, Arho; Brändli, Johanna; Schillberg, Stefan; Eibl-Schindler, Regine; Bouwmeester, Harro; Oksman-Caldentey, Kirsi-Marja,

2014.

Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway.

Journal of Biotechnology.

176, pp. 20-28.

Available from: https://doi.org/10.1016/j.jbiotec.2014.01.031
Jossen, Valentin; Kaiser, Stephan C.; Schirmaier, Carmen; Hermann, Jacqueline; Tappe, Alexander; Eibl, Dieter; Siehoff, Ann; van den Bos, Christian; Eibl-Schindler, Regine,

2014.

Modification and qualification of a stirred single-use bioreactor for the improved expansion of human mesenchymal stem cells at benchtop scale.

Pharmaceutical Bioprocessing.

2(4), pp. 311-322.
Löffelholz, Christian; Husemann, Ute; Greller, Gerhard; Meusel, Wolfram; Kauling, Jörg; Ay, Peter; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter,

2013.

Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods.

Chemie Ingenieur Technik.

85(1-2), pp. 40-56.

Available from: https://doi.org/10.1002/cite.201200125
Kaiser, Stephan; Jossen, Valentin; Schirmaier, Carmen; Eibl, Dieter; Brill, Silke; van den Bos, Christian; Eibl-Schindler, Regine,

2013.

Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors.

Chemie Ingenieur Technik.

85(1-2), pp. 95-102.

Available from: https://doi.org/10.1002/cite.201200180
Blaschczok, Katharina; Kaiser, Stephan C.; Löffelholz, Christian; Imseng, Nicole; Burkart, Jürg; Bösch, Pascal; Dornfeld, Wolfgang; Eibl-Schindler, Regine; Eibl, Dieter,

2013.

Investigations on mechanical stress caused to CHO suspension cells by standard and single-use pumps.

Chemie Ingenieur Technik.

85(1-2), pp. 144-152.

Available from: https://doi.org/10.1002/cite.201200135
Lehmann, Nicolai; Rischer, Heiko; Eibl, Dieter; Eibl-Schindler, Regine,

2013.

Wave-mixed and orbitally shaken single-use photobioreactors for diatom algae propagation.

Chemie Ingenieur Technik.

85(1-2), pp. 197-201.

Available from: https://doi.org/10.1002/cite.201200137
Stefanache, Camelia Paula; Imseng, Nicole; Meier, Beat; Tanase, Catalin; Eibl-Schindler, Regine; Peter, Samuel; Wolfram, Evelyn,

2013.

Arnica montana L. cell suspension culture as a biotechnological approach for the production of bioactive secondary metabolites.

Planta Medica.

79(13).

Available from: https://doi.org/10.1055/s-0033-1352447
Georgiev, Milen I.; Eibl-Schindler, Regine; Zhong, Jian-Jiang,

2013.

Hosting the plant cells in vitro : recent trends in bioreactors.

Applied Microbiology and Biotechnology.

97(9), pp. 3787-3800.

Available from: https://doi.org/10.1007/s00253-013-4817-x
Steiger, Nina; Eibl-Schindler, Regine,

2013.

Interlaboratory test for detection of cytotoxic leachables arising from single-use bags.

Chemie Ingenieur Technik.

85(1-2), pp. 26-28.

Available from: https://doi.org/10.1002/cite.201200171
Bogli, Nicole C.; Ries, Christoph; Adams, Thorsten; Greller, Gerhard; Eibl, Dieter; Eibl-Schindler, Regine,

2012.

Large-scale, insect-cell-based vaccine development.

BioProcess International.

10(2).

Available from: http://www.bioprocessintl.com/upstream-processing/upstream-single-use-technologies/large-scale-insect-cellbased-vaccine-development-330217/?pageNum=3
Kaiser, Stephan; Eibl-Schindler, Regine; Eibl, Dieter,

2011.

Engineering characteristics of a single-use stirred bioreactor at benchtop scale : the Mobius CellReady 3 L bioreactor as case study.

Engineering in Life Sciences.

11(4), pp. 359-368.

Available from: https://doi.org/10.1002/elsc.201000171
Werner, Sören; Eibl-Schindler, Regine; Lettenbauer, Christine; Röll, Marcel; Eibl, Dieter; De Jesus, Maria; Zhang, Xiaowei; Stettler, Matthieu; Tissot, Stephanie; Bürkie, Cedric; Broccard, Gilles; Kühner, Markus; Tanner, Rolf; Baldi, Lucia; Hacker, David; Wurm, Florian M.,

2010.

Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution.

Chimia.

64(11), pp. 819-823.

Available from: https://doi.org/10.2533/chimia.2010.819
Eibl-Schindler, Regine; Kaiser, Stephan; Lombriser, Renate; Eibl, Dieter,

2010.

Disposabe bioreactors : the current state-of-the-art and recommended applications in biotechnology.

Applied Microbiology and Biotechnology.

86(1), pp. 41-49.

Available from: https://doi.org/10.1007/s00253-009-2422-9
Ries, Christoph; John, Gernot; John, Corinne; Eibl-Schindler, Regine; Eibl, Dieter,

2010.

A shaken disposable bioreaktor system for controlled insect cell cultivations at millilitre-scale.

Engineering in Life Sciences.

10(1), pp. 75-79.

Available from: https://doi.org/10.1002/elsc.200900040
Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

2009.

Disposable bioreactors for plant liquid cultures at litre-scale.

Engineering in Life Sciences.

9(3), pp. 156-164.

Available from: https://doi.org/10.1002/elsc.200800102
Eibl-Schindler, Regine; Eibl, Dieter,

2009.

Disposable bioreactors in cell culture-based upstream processing.

BioProcess International.

7(1), pp. 18-23.

Available from: http://www.bioprocessintl.com/upstream-processing/cell-culture-media/disposable-bioreactors-in-cell-culture-based-upstream-processing-184055/
Eibl-Schindler, Regine; Eibl, Dieter,

2007.

Design of bioreactors suitable for plant cell and tissue cultures.

Phytochemistry Reviews.

7(3), pp. 593-598.

Available from: https://doi.org/10.1007/s11101-007-9083-z
Bonfill, M.; Bentebibel, S.; Moyano, E.; Palazón, J.; Cusidó, R. M.; Eibl-Schindler, Regine; Piñol, M. T.,

2007.

Paclitaxel and baccatin III production induced by methyl jasmonate in free and immobilized cells of Taxus baccata.

Biologia Plantarum.

51(4), pp. 647-652.

Available from: https://doi.org/10.1007/s10535-007-0137-2
Bentebibel, Salima; Moyano, Elisabet; Palazón, Javier; Cusidó, Rosa M.; Bonfill, Mercedes; Eibl-Schindler, Regine; Piñol, M. Teresa,

2005.

Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata.

Biotechnology & Bioengineering.

89(6), pp. 647-655.

Available from: https://doi.org/10.1002/bit.20321
Palazón, Javier; Mallol, Anna; Eibl-Schindler, Regine; Lettenbauer, Christine; Cusidó, Rosa M.; Piñol, M. Teresa,

2003.

Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor.

Planta Medica.

69(4), pp. 344-349.

Available from: https://doi.org/10.1055/s-2003-38873

Books and monographs, peer-reviewed

Eibl-Schindler, Regine; Eibl, Dieter, eds.,

2019.

Single-use technology in biopharmaceutical manufacture.

2nd Edition.

Wiley.

ISBN 978-1-119-47783-9.

Available from: https://doi.org/10.1002/9781119477891
Eibl, Dieter; Eibl-Schindler, Regine, eds.,

2013.

Disposable bioreactors II.

Berlin:

Springer.

Advances in Biochemical Engineering/Biotechnology ; 138.

ISBN 978-3-642-45157-7.

Available from: https://doi.org/10.1007/978-3-642-45158-4
Eibl-Schindler, Regine; Eibl, Dieter, eds.,

2011.

Single-use technology in biopharmaceutical manufacture.

Hoboken:

Wiley.

ISBN 978-0-470-43351-5.

Available from: https://doi.org/10.1002/9780470909997
Eibl-Schindler, Regine; Eibl, Dieter, eds.,

2010.

Disposable bioreactors.

Berlin:

Springer.

Advances in Biochemical Engineering/Biotechnology.

ISBN 978-3-642-01871-8.

Available from: https://doi.org/10.1007/978-3-642-01872-5

Book parts, peer-reviewed

Seidel, Stefan; Schirmer, Cedric; Maschke, Rüdiger; Rossi, Lia; Eibl-Schindler, Regine; Eibl, Dieter,

2023.

Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review

.

In:

Ji, Guozhao; Dong, Jingliang, eds.,

Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications.

London:

IntechOpen Limited.

pp. 53-82.

Available from: https://doi.org/10.5772/intechopen.109848
Seidel, Stefan; Schirmer, Cedric; Maschke, Rüdiger; Rossi, Lia; Eibl-Schindler, Regine; Eibl, Dieter,

2023.

Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies

.

In:

Ji, Guozhao; Dong, Jingliang, eds.,

Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications.

London:

IntechOpen Limited.

pp. 83-98.

Available from: https://doi.org/10.5772/intechopen.109849
Jossen, Valentin; Eibl-Schindler, Regine; Broccard, Gilles; Eibl, Dieter,

2023.

Single-use systems in biopharmaceutical manufacture : state of the art and recent trends

.

In:

Pörtner, Ralf, ed.,

Biopharmaceutical Manufacturing : Progress, Trends and Challenges.

Cham:

Springer.

pp. 3-38.

Cell Engineering ; 11.

Available from: https://doi.org/10.1007/978-3-031-45669-5_1
Teale, Misha; Jossen, Valentin; Eibl, Dieter; Eibl-Schindler, Regine,

2021.

Chemically defined, xeno-free expansion of human mesenchymal stem cells (hMSCs) on benchtop-scale using a stirred single-use bioreactor

.

In:

Turksen, Kursad, ed.,

Bioreactors in Stem Cell Biology : Methods and Protocols.

New York, NY:

Humana.

pp. 83-111.

Methods in Molecular Biology ; 2436.

Available from: https://doi.org/10.1007/7651_2021_426
Müller, Jan; Teale, Misha; Steiner, Sandra; Junne, Stefan; Neubauer, Peter; Eibl, Dieter; Eibl-Schindler, Regine,

2021.

Intensified and continuous mAb production with single-use systems

.

In:

Pörtner, Ralf, ed.,

Cell Culture Engineering and Technology.

Cham:

Springer.

pp. 401-429.

Cell Engineering ; 10.

Available from: https://doi.org/10.1007/978-3-030-79871-0_13
Jossen, Valentin; Eibl, Dieter; Eibl, Regine,

2020.

Numerical methods for the design and description of in vitro expansion processes of human mesenchymal stem cells

.

In:

Digital Twins.

Berlin:

Springer.

pp. 185-228.

Advances in Biochemical Engineering / Biotechnology ; 177.

Available from: https://doi.org/10.1007/10_2020_147
Schirmer, Cedric; Müller, Jan; Steffen, Nina; Werner, Sören; Eibl-Schindler, Regine; Eibl, Dieter,

2020.

How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale

.

In:

Pörtner, Ralf, ed.,

Animal cell biotechnology : methods and protocols.

New York:

Springer.

pp. 169-186.

Methods in Molecular Biology ; 2095.

Available from: https://doi.org/10.1007/978-1-0716-0191-4_10
Werner, Sören; Maschke, Rüdiger W.; Eibl, Dieter; Eibl, Regine,

2018.

Bioreactor technology for sustainable production of plant cell-derived products

.

In:

Pavlov, Atanas; Bley, Thomas, eds.,

Bioprocessing of Plant In Vitro Systems.

Cham:

Springer.

pp. 413-432.

Reference Series in Phytochemistry.

Available from: https://doi.org/10.1007/978-3-319-54600-1_6
Schirmer, Cedric; Nussbaumer, Thomas; Schöb, Reto; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter,

2018.

Development, engineering and biological characterization of stirred tank bioreactors

.

In:

Yeh, Ming-Kung; Chen, Yuan-Chuan, eds.,

Biopharmaceuticals.

London:

IntechOpen.

pp. 87-107.

Available from: https://doi.org/10.5772/intechopen.79444
Jossen, Valentin; Eibl-Schindler, Regine; Pörtner, Ralf; Kraume, Matthias; Eibl, Dieter,

2017.

Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes

.

In:

Current Developments in Biotechnology and Bioengineering.

Elsevier.

pp. 179-215.

Available from: https://doi.org/10.1016/B978-0-444-63663-8.00007-0
Löffelholz, Christian; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl-Schindler, Regine,

2014.

Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up

.

In:

Eibl, Dieter; Eibl-Schindler, Regine, eds.,

Disposable bioreactors II.

Berlin:

Springer.

pp. 1-41.

Advances in Biochemical Engineering/Biotechnology ; 138.

Available from: https://doi.org/10.1007/10_2013_187
Eibl-Schindler, Regine; Steiger, Nina; Wellnitz, Sabine; Vicente, Tiago; John, Corinne; Eibl, Dieter,

2014.

Fast single-use VLP vaccine productions based on insect cells and the baculovirus expression vector system : influenza as case study

.

In:

Eibl, Dieter; Eibl-Schindler, Regine, eds.,

Disposable bioreactors II.

Berlin:

Springer.

pp. 99-125.

Advances in Biochemical Engineering/Biotechnology ; 138.

Available from: https://doi.org/10.1007/10_2013_186
Eibl-Schindler, Regine; Löffelholz, Christian; Eibl, Dieter,

2011.

Single-use bioreactors : an overview

.

In:

Eibl-Schindler, Regine; Eibl, Dieter, eds.,

Single-use technology in biopharmaceutical manufacture.

Hoboken:

Wiley.

pp. 145-158.

Available from: https://doi.org/10.1002/9780470909997.ch4
Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

2010.

Bag bioreactor based on wave-induced motion : characteristics and applications

.

In:

Eibl-Schindler, Regine; Eibl, Dieter, eds.,

Disposable Bioreactors.

Berlin:

Springer.

pp. 55-87.

Advances in Biochemical Engineering / Biotechnology ; 115.

Available from: https://doi.org/10.1007/10_2008_15
Eibl-Schindler, Regine; Eibl, Dieter,

2009.

Application of disposable bag-bioreactors in tissue engineering and for production of therapeutic agents

.

In:

Kasper, Cornelia; van Griensven, Martijn; Pörtner, Ralf, eds.,

Bioreactor systems for tissue engineering.

Berlin:

Springer.

pp. 183-207.

Advances in Biochemical Engineering/Biotechnology ; 112.

Available from: https://doi.org/10.1007/10_2008_23

Conference contributions, peer-reviewed

Schirmer, Cedric; Ott, Vivian; Müller, Jan; Göhmann, Rüdiger; Biewald, Andreas; Eibl-Schindler, Regine; Eibl, Dieter,

2022.

Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale [poster].

In:

27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.

ESACT, European Association for Animal Cell Technology.

Other publications

Seidel, Stefan; Maschke, Rüdiger W.; Kraume, Matthias; Eibl-Schindler, Regine; Eibl, Dieter,

2023.

Advanced numerical characterization of a wave-mixed bioreactor used in the biopharmaceutical industry [paper].

In:

Engineering Conferences International (ECI), Single Use Technologies VI: Established, Emergent, Agile, Sustainable?, Boston, USA, 10-13 September 2023.
Seidel, Stefan; Maschke, Rüdiger W.; Mozaffari, Fruhar; Eibl-Schindler, Regine; Eibl, Dieter,

2023.

Prediction of the aggregate size distribution of HEK293 cells based on computational fluid dynamics [poster].

In:

Himmelfahrtstagung on Bioprocess Engineering 2023 - Novel production routes and processes for bio-pharmaceuticals and industrial bioeconomy, Weimar, Germany, 15-17 May 2023.
Ott, Vivian; Müller, Jan; Eibl-Schindler, Regine; Eibl, Dieter; Schirmer, Cedric; Göhmann, Rüdiger; Biewald, Andreas,

2022.

A new single-use disk stack separator for pilot scale CHO cell-based antibody productions [poster].

In:

ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.

Available from: https://dc.engconfintl.org/sut_v/11/
Bayer, Marcus; Castan, Andreas; Eibl, Regine; Eibl, Dieter; Eisenkrätzer, Detlef; Fritz, Christina; Glaser, Robert; Glenz, Martin; Greller, Gerhard; Hug, Michelle; Kleebank, Sebastian; Kampmann, Markus; Krättli, Martin; Manser, Britta; Matuszczyk, Jens; Ottinger, Melanie; Schleper, Stefan; Schreiber, Marko; Seidel, Stefan; Selzer, Sebastian; Tanner, Markus; Teale, Misha; Tiemann, Karin,

2020.

Technical state-of-the-art and risk analysis on single-use equipment in continuous processing steps.

Frankfurt am Main:

DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V..

ISBN 978-3-89746-226-7.

Available from: https://doi.org/10.21256/zhaw-26357
Jossen, Valentin; Eberle, Sebastian; Muoio, Francesco; Panella, Stefano; Tallone, Tiziano; Moccetti, Tiziano; Lindner, Matias; Müller, Michele; Eibl, Dieter; Eibl-Schindler, Regine; et al.,

2019.

Serum-free hMSC expansion in stirred single-use cultivation systems [poster].

In:

BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.
van den Bos, Christian; Jossen, Valentin; Eibl, Dieter; Eibl-Schindler, Regine,

2019.

Advanced therapy medicinal products (ATMPs) & GMP : 10 years after.

Die Pharmazeutische Industrie : pharmind.

81(4), pp. 508-513.
Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

2019.

Single‐use bioreactors : an overview

.

In:

Single‐Use Technology in Biopharmaceutical Manufacture.

Wiley.

pp. 37-52.

Available from: https://doi.org/10.1002/9781119477891.ch4
Jossen, Valentin; Eibl-Schindler, Regine; Kraume, Matthias; Eibl, Dieter,

2018.

Growth behavior of human adipose tissue-derived stromal/stem cells in single-use spinner flasks : numerical and experimental investigations [poster].

In:

ECI: Single Use Technologies III: Scientific and Technological Advancements, Utah, USA, 23-26 September 2018.
Schildberger, David; Stutz, Irene; Weber, Carlo; Pedan, Vasilisa; Schlüter, Ansgar; Huber, Petra; Chatelain, Karin; Chetschik, Irene; Eibl, Dieter; Hühn, Tilo; Eibl-Schindler, Regine,

2018.

Cast off! Chocolate from cacao cell cultures [poster].

In:

New Harvest 2018 Conference, Cambridge, USA, 20-21 July 2018.
Eibl-Schindler, Regine; Eibl, Dieter,

2017.

Single-Use-Systeme in der biopharmazeutischen Produktion : Chancen und Herausforderungen.

Die Pharmazeutische Industrie : pharmind.

79, pp. 719-724.
Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

2016.

Expansion of human adipose tissue-derived stromal/stem cells in a wave-mixed single-use bioreactor : a proof-of-concept [poster].

In:

BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.
Jossen, Valentin; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

2016.

Impact of shear stress on cell growth and microcarrier-cell-agglomerate formation in microcarrier-based cultivations of adipose tissue-derived stromal/stem cells [poster].

In:

BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.
Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

2016.

How to successfully scale up a microcarrier based expansion process of human mesenchymal stem cells from adipose tissue [poster].

In:

4th BioProScale Symposium 2016, Berlin, Germany, 6-8 April 2016.
Jossen, Valentin; Schirmaier, Carmen; John, Gernot T.; Eibl, Dieter; Eibl-Schindler, Regine,

2015.

On-line-pH- und -DO-Messungen in Mikrocarrier-basierter hMSC Kultur.

BIOspektrum.

21(4), pp. 422-424.

Available from: https://doi.org/10.1007/s12268-015-0597-4
Eibl-Schindler, Regine; Eibl, Dieter,

2015.

Single-use (disposable) systems in biopharmaceutical processing : quo vadis?.

ACHEMA Trend Reports.

13.
Jossen, Valentin; Pörtner, Ralf; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl-Schindler, Regine,

2014.

Mass production of mesenchymal stem cells — impact of bioreactor design and flow conditions on proliferation and differentiation

.

In:

Eberli, Daniel, ed.,

Cells and Biomaterials in Regenerative Medicine.

InTech.

pp. 119-172.

Tissue Engineering and Regenerative Medicine.

Available from: https://doi.org/10.5772/59385
Jossen, Valentin; Schirmaier, Carmen; John, Gernot; Siehoff, Ann; Eibl, Dieter; Eibl-Schindler, Regine,

2014.

Online pH and DO measurement in microcarrier-based hMSC cultivations performed in single-use spinner flask [poster].

In:

BioTech 2014, Wädenswil, Switzerland, 4-5 September 2014.
Jossen, Valentin; Ott, Anita; Kaiser, Stephan; Brill, Silke; Spicker, Sonja; Safavi-nab, Agnieszka; Jüngerkes, Frank; Siehoff, Ann; Rosenbaum, Claudia; Reinisch, Barbara; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine; et al.,

2014.

Microcarrier-based expansion of adipose tissue and bone marrow derived human mesenchymal stem cells in therapeutically relevant doses [poster].

In:

4th Lugano Stem Cell Meeting, Lugano, Switzerland, 23-24 June 2014.
Jossen, Valentin; Kaiser, Stephan; Schirmaier, Carmen; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

2013.

Investigations of fluif flow and microcarrier suspension for hMSC expansion in single-use stirred bioreactors [poster].

In:

BioTech 2013, Wädenswil, Switzerland, 3-5 June 2013.
Eibl, Dieter; Eibl, Regine; Eisenkrätzer, Detlef; Tiemann, Karin,

2013.

TAK „Single-Use-Technologien in der biopharmazeutischen Produktion“.

BIOspektrum.

19(4), pp. 454-455.

Available from: https://doi.org/10.1007/s12268-013-0334-9
Brändli, Johanna; Müller, Matthias; Imseng, Nicole; Schillberg, Stefan; Eibl-Schindler, Regine,

2012.

Antikörper-Produktion in Pflanzenzellen : Prozessentwicklung und -übertragung vom 50-ml- auf den 10-l-Maßstab.

BIOspektrum.

18(2), pp. 216-217.

Available from: https://doi.org/10.1007/s12268-012-0166-z
Eibl-Schindler, Regine; Eibl, Dieter,

2011.

Single-use cell culture systems arrive : tracking the evolution and development of an increasingly used technology.

Genetic Engineering & Biotechnology News.

31(17), pp. 59-61.

Available from: https://doi.org/10.1089/gen.31.17.15
Eibl-Schindler, Regine,

2011.

Zellkultivierung in einem wellendurchmischten, DO-regulierten Einwegbioreaktor.

Bioforum.

34(1), pp. 22-23.
Eibl, Regine; Eibl, Dieter; Pörtner, Ralf; Catapano, Gerardo; Czermak, Peter, eds.,

2009.

Cell and tissue reaction engineering.

Berlin:

Springer.

Principles and Practice.

ISBN 978-3-540-68175-5.

Available from: https://doi.org/10.1007/978-3-540-68182-3
Ries, Christoph; John, C.; Eibl-Schindler, Regine,

2009.

Einwegbioreaktoren für die Prozessentwicklung mit Insektenzellen.

Bioforum.

3, pp. 11-13.
Eibl-Schindler, Regine; Eibl, Dieter,

2007.

Disposable bioreactors for cell culture based-processing.

Achema Worldwide News.

2, pp. 8-10.
Eibl, Dieter; Eibl-Schindler, Regine,

2007.

Einwegbioreaktoren für Zellkulturen : Status quo und Trends.

Pharma-Tec.

4, pp. 14-15.
Cuperus, S.; Eibl-Schindler, Regine; Hühn, Tilo; Amado, R.,

2007.

Plant cell culture based platform investigating biochemical processes in wine production.

BioForum Europe.

6, pp. 2-4.
Eibl-Schindler, Regine; Eibl, Dieter,

2005.

Einwegkultivierungstechnologie für biotechnische Pharma-Produktionen.

BioWorld.

3.
Eibl-Schindler, Regine; Rutschmann, K.; Lisica, Lidija; Eibl, Dieter,

2003.

Kostenreduktion bei der Säugerzellkultivierung durch Einwegbioreaktoren?.

BioWorld.

5, pp. 22-23.
Eibl-Schindler, Regine,

2002.

Fermentative Herstellung bioaktiver Wirkstoffe.

BioWorld.

6(Beilage).
Viviani, A.; Eibl-Schindler, Regine,

2001.

Rote Biotechnologie.

BioWorld.

4(Beilage).
Eibl-Schindler, Regine; Brändli, Johanna; Lettenbauer, C.; Eibl, Dieter,

2000.

Kultivierung pflanzlicher und animaler Zellkulturen.

BioWorld.

5, pp. 48-50.
Eibl-Schindler, Regine; Lettenbauer, C.; Eibl, Dieter; Röllin, Markus,

1999.

Experiences in the application of the wave bioreactor.

BioForum Europe.

3, pp. 110-112.
Eibl-Schindler, Regine; Hans, Daniel; Warlies, S.; Lettenbauer, C.; Eibl, Dieter,

1999.

Zellkulturtechnik : Einsatz eines Taumelreaktorsystems mit interner Beleuchtung.

BioWorld.

2, pp. 10-12.
Eibl-Schindler, Regine,

1996.

Pflanzenzellkulturtechnik an der Ingenieurschule Wädenswil.

BioWorld.

5, pp. 3-7.

Oral conference contributions and abstracts

Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

2018.

Multiphase CFD simulations for supporting MC-based hMSC process development.

In:

5th BioProScale Symposium, Berlin, Germany, 20-22 March 2018.
Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf,

2017.

Standardized expansion of human adipose tissue-derived stromal/stem cells (hASCs) in wave-mixed single-use bioreactors with one-dimensional motion.

In:

ECI: Single Use Technologies II: Bridging Polymer Science to Bioprocess Applications, Tomar, Portugal, 7–10 May 2017.

Available from: https://pdfs.semanticscholar.org/9a61/98bcd2e950104f1457e8f0e7c7380323ebf5.pdf
Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

2017.

How to use Computational Fluid Dynamics in the development of cell therapeutics.

In:

ECI: Scale-up and Manufacturing of Cell-based Therapies V, San Diego, USA, 15-19 January 2017.
Schirmer, Cedric; Jossen, Valentin; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Böttcher, Lars; Eibl, Dieter,

2016.

Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors.

In:

ILMAC, Basel, 2016.
Jossen, Valentin; Eibl, Dieter; Eibl-Schindler, Regine,

2015.

How can Computational Fluid Dynamics be used in order to rapidly expand bone marrow derived hMSCs in clinically relevant numbers.

In:

DECHEMA Himmelfahrtstagung, Hamburg, Germany, 11-13 May 2015.
Eibl-Schindler, Regine; Jossen, Valentin; Eibl, Dieter,

2015.

Mass production of hMSCs : an approach based on stirred single-use bioreactors.

In:

ECI: Scale-up and Manufacturing of Cell-based Therapies III, 18-22 January 2015.
Jossen, Valentin; Kaiser, Stephan; Siehoff, Ann; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

2014.

A successful approach in order to rapidly scaling-up microcarrier-based expansion of human mesenchymal stem cells for allogeneic therapies.

In:

3rd International Conference on Tissue Science & Regenerative Medicine, Valencia, Spain, 24-26 September 2014.
Jossen, Valentin; Kaiser, Stephan; Eibl-Schindler, Regine; Eibl, Dieter,

2014.

Numerische Strömungsuntersuchungen für die Massstabsübertragung der Expansion von humanen mesenchymalen Stammzellen in gerührten Single-Use Bioreaktoren.

In:

17. Köthener-Rührer-Kolloquium, Köthen, Deutschland, 26. Juni 2014.
Jossen, Valentin; Kaiser, Stephan; Ott, Anita; Siehoff, Ann; Brill, Silke; Greller, Gerhard; Tappe, Alexander; Eibl-Schindler, Regine; Eibl, Dieter; et al.,

2014.

Optimization of a benchtop single-use bioreactor for the expansion of adipose-tissue and bone marrow derived human mesenchymal stem cells.

In:

41st Annual European Society for Artificial Organs Congress, Rome, Italy, 17-20 September 2014.

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