Cedric Schirmer

Work at ZHAW

Focus

• Process engineering characterisation and development of bioreactors
• Bioprocess and fermentation engineering
• Scale-up of microbial and cell culture processes
• Single-use technology for biopharmaceutical manufacturing
• Computational Fluid Dynamics (CFD)
• Cell culture technology, animal cells, human mesenchymal stem cells

Network

Membership of networks

DECHEMA

ORCID digital identifier

ORCID ID: 0000-0002-5779-4337

Projects

• Process development and biomass production of S. cerevisiae spiked with heavy water / Co-project leader / abgeschlossen
• Evaluation of cell separation using the GEA kytero® Single Use Pharma Separator with disk stack technology / Project leader / abgeschlossen
• Muscle generator – The key to unlock scalable and affordable cultivated meat production / Project leader / abgeschlossen
• Microbiome therapeutics / Deputy project leader / abgeschlossen

Publications

• Ott, Vivian; Müller, Jan; Schirmer, Cedric; Weiss, Noémi; Göhmann, Rüdiger; Biewald, Andreas; Michel, Andrej; Eibl, Dieter; Eibl-Schindler, Regine,

  2022.

  Qualification of a single‐use disk stack separator for cell separation in mammalian cell‐based antibody production.

  Chemie Ingenieur Technik.

  94(12), pp. 1936-1943.

  Available from: https://doi.org/10.1002/cite.202200096

• Schirmer, Cedric; Eibl-Schindler, Regine; Maschke, Rüdiger; Mozaffari, Fruhar; Junne, Stefan; Daumke, Ralph; Ottinger, Melanie; Göhmann, Rüdiger; Ott, Christian; Wenk, Irina; Kubischik, Jens; Eibl, Dieter,

  2022.

  Single‐use technology for the production of cellular agricultural products : where are we today?.

  Chemie Ingenieur Technik.

  94(12), pp. 2018-2025.

  Available from: https://doi.org/10.1002/cite.202200092

• Schirmer, Cedric; Maschke, Rüdiger; Pörtner, Ralf; Eibl, Dieter,

  2021.

  An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes.

  Applied Microbiology and Biotechnology.

  Available from: https://doi.org/10.1007/s00253-021-11180-7

• Schirmer, Cedric; Blaschczok, Katharina; Husemann, Ute; Leupold, Marco; Zahnow, Christian; Rupprecht, Jens; Glöckler, Rainer; Greller, Gerhard; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter,

  2017.

  Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes.

  Chemie Ingenieur Technik.

  89(12).

  Available from: https://doi.org/10.1002/cite.201700039

• Jossen, Valentin; Schirmer, Cedric; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes.

  Stem Cells International.

  2016(4760414).

  Available from: https://doi.org/10.1155/2016/4760414

• Seidel, Stefan; Schirmer, Cedric; Maschke, Rüdiger; Rossi, Lia; Eibl-Schindler, Regine; Eibl, Dieter,

  2023.

  Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part I: literature review

  .

  In:

  Ji, Guozhao; Dong, Jingliang, eds.,

  Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications.

  London:

  IntechOpen Limited.

  pp. 53-82.

  Available from: https://doi.org/10.5772/intechopen.109848

• Seidel, Stefan; Schirmer, Cedric; Maschke, Rüdiger; Rossi, Lia; Eibl-Schindler, Regine; Eibl, Dieter,

  2023.

  Computational fluid dynamics for advanced characterisation of bioreactors used in the biopharmaceutical industry : part II: case studies

  .

  In:

  Ji, Guozhao; Dong, Jingliang, eds.,

  Computational Fluid Dynamics - Recent Advances, New Perspectives and Applications.

  London:

  IntechOpen Limited.

  pp. 83-98.

  Available from: https://doi.org/10.5772/intechopen.109849

• Schirmer, Cedric; Müller, Jan; Steffen, Nina; Werner, Sören; Eibl-Schindler, Regine; Eibl, Dieter,

  2020.

  How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale

  .

  In:

  Pörtner, Ralf, ed.,

  Animal cell biotechnology : methods and protocols.

  New York:

  Springer.

  pp. 169-186.

  Methods in Molecular Biology ; 2095.

  Available from: https://doi.org/10.1007/978-1-0716-0191-4_10

• Schirmer, Cedric; Rothe, Sebastian; Jenness, Ernest; Eibl, Dieter,

  2019.

  Systems for coupling and sampling

  .

  In:

  Eibl, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 53-68.

  Available from: https://doi.org/10.1002/9781119477891.ch5

• Schirmer, Cedric; Nussbaumer, Thomas; Schöb, Reto; Pörtner, Ralf; Eibl-Schindler, Regine; Eibl, Dieter,

  2018.

  Development, engineering and biological characterization of stirred tank bioreactors

  .

  In:

  Yeh, Ming-Kung; Chen, Yuan-Chuan, eds.,

  Biopharmaceuticals.

  London:

  IntechOpen.

  pp. 87-107.

  Available from: https://doi.org/10.5772/intechopen.79444

• Schirmer, Cedric; Ott, Vivian; Müller, Jan; Göhmann, Rüdiger; Biewald, Andreas; Eibl-Schindler, Regine; Eibl, Dieter,

  2022.

  Qualification of a single-use disk stack separator for modern mAb upstream processing at pilot scale [poster].

  In:

  27th ESACT Meeting, Lisbon, Portugal, 26-29 June 2022.

  ESACT, European Association for Animal Cell Technology.

• Ott, Vivian; Müller, Jan; Eibl-Schindler, Regine; Eibl, Dieter; Schirmer, Cedric; Göhmann, Rüdiger; Biewald, Andreas,

  2022.

  A new single-use disk stack separator for pilot scale CHO cell-based antibody productions [poster].

  In:

  ECI: Single-Use Technologies V: Building The Future, Marseille, France, 20-23 March 2022.

  Available from: https://dc.engconfintl.org/sut_v/11/

• Schirmer, Cedric; Ott, Vivian; John, Gernot T.; Eibl, Dieter,

  2020.

  Integration of chemical-optical oxygen and pH sensors in existing control units : cultivation monitoring in a glass bioreactor system with subsequently integrated sensor spots.

  PreSens Publications.

  Available from: https://www.presens.de/knowledge/publications/application-note/integration-of-chemical-optical-oxygen-and-ph-sensors-in-existing-control-units-1692

• Schirmer, Cedric; Dreher, Thomas; Leupold, Marco; Glaser, Robert; Castan, Andreas; Brown, Jason; Eibl, Dieter; Glöckler, Rainer,

  2019.

  Recommendation for biological evaluation of bioreactor performance for microbial processes.

  2. revised edition.

  Frankfurt am Main:

  DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie e.V..

  ISBN 978-3-89746-222-9.

  Available from: https://dechema.de/dechema_media/Downloads/Positionspapiere/SingleUse_Microbial_ezl+2Ed+Sept2019-p-20005491.pdf

• Schirmer, Cedric; Nussbaumer, Thomas; Schöb, Reto; Pörtner, Ralf; Eibl, Dieter,

  2019.

  Development of an universally useable single-use bioreactor for the benchtop scale [poster].

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

• Rossi, Lia; Schirmer, Cedric; Teale, Misha; Kurt, Fabienne; Rosenthal, Florian; Eibl, Dieter,

  2019.

  Proof of concept study for cultivation of strict anaerobes in a single-use wave-mixed bioreactor [poster].

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

• Schirmer, Cedric; Nussbaumer, Thomas; Schöb, Reto; Pörtner, Ralf; Eibl, Dieter,

  2019.

  A universal stirred bioreactor for the development of biotherapeutics [poster].

  In:

  DECHEMA Himmelfahrtstagung: Intensification and digitalisation for integral bioprocessing, Hamburg, Germany, 27-29 May 2019.

  DECHEMA, Gesellschaft für Chemische Technik und Biotechnologie.

• Werner, Sören; Schirmer, Cedric; Steffen, Nina; Müller, Jan; Becheau, Odette; Cameau, Emmanuelle; Welsh, John H.; Jones, Kyle; Capone, Joe; Collignon, Marie-Laure,

  2019.

  Performance comparison of CHO-S cell cultivation and mAb production in the Allegro™ STR 200 single-use bioreactor and in conventional single-use bioreactor [poster].

  In:

  26th ESACT Meeting, Copenhagen, Denmark, 5-8 May 2019.

  Available from: https://www.pall.com/en/biotech/posters-presentations/performance-comparison-cho-s-cell-cultivation-mab-production-allegro-str-200-single-use-bioreactor-conventional-single-use-bioreactor.html

• Schirmer, Cedric; Eibl, Dieter,

  2017.

  Rührwerk für moderne Bioreaktoren.

  Transfer.

  2017(2), pp. 4.

  Available from: https://doi.org/10.21256/zhaw-19304

• von Blarer, Damian; Senn, Yannick; Kienle, Klaus; Schirmer, Cedric; Blaschczok, Katharina; Husemann, Ute; Greller, Gerhard; Leupold, Marco; Rupprecht, Jens; Glöckler, Rainer; Eibl, Dieter,

  2016.

  Biological bioreactor characterization by means of an Escherichia coli model process [poster].

  In:

  BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.

• Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  Expansion of human adipose tissue-derived stromal/stem cells in a wave-mixed single-use bioreactor : a proof-of-concept [poster].

  In:

  BioTech 2016, Wädenswil, Switzerland, 5-8 September 2016.

• Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  How to successfully scale up a microcarrier based expansion process of human mesenchymal stem cells from adipose tissue [poster].

  In:

  4th BioProScale Symposium 2016, Berlin, Germany, 6-8 April 2016.

• Schirmer, Cedric,

  2022.

  Animal cell culture-based cellular agriculture : basics and challenges of clean meat production.

  In:

  XVI. Biotechnet Summer School on Advanced Biotechnology, Innsbruck, Austria, 12-15 September 2022.

• Seidel, Stefan; Schirmer, Cedric; Eibl, Dieter,

  2022.

  Integration of a drive system based on magnetic levitation technology to power a stirred bioreactor.

  In:

  Levitronix Bioprocessing Conference, Boston, USA, 2 June 2022.

  Available from: https://www.levitronix.com/app/uploads/2022/06/Stefan-2_1.mp4

• Schirmer, Cedric,

  2020.

  Shear stress investigations on Levitronix single-use centrifugal pumps.

  In:

  Levitronix Bioprocessing Conference, Live Webinar Part 2, 27 May 2020.

• Schirmer, Cedric; Kienle, Klaus,

  2019.

  Comparison of stirred single-use bioreactors : case study of an IgG production process.

  In:

  BioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, Switzerland, 2-4 July 2019.

• Schirmer, Cedric,

  2019.

  Biological evaluation of bioreactor performance for microbial processes.

  In:

  Knowledge Culture Workshop : Large-scale fermentation, Cramlington, United Kingdom, May 2019.

• Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf,

  2017.

  Standardized expansion of human adipose tissue-derived stromal/stem cells (hASCs) in wave-mixed single-use bioreactors with one-dimensional motion.

  In:

  ECI: Single Use Technologies II: Bridging Polymer Science to Bioprocess Applications, Tomar, Portugal, 7–10 May 2017.

  Available from: https://pdfs.semanticscholar.org/9a61/98bcd2e950104f1457e8f0e7c7380323ebf5.pdf

• Schirmer, Cedric; Jossen, Valentin; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Böttcher, Lars; Eibl, Dieter,

  2016.

  Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors.

  In:

  ILMAC, Basel, 2016.

Publications before appointment at the ZHAW

• Goepfert, Christiane; Blume, Grit; Faschian, Rebecca; Meyer, Stefanie; Schirmer, Cedric; Müller-Wichards, Wiebke; Müller, Jörg; Fischer, Janine; Feyerabend, Frank; Pörtner, Ralf, 2013. A modular flow-chamber bioreactor concept as a tool for continuous 2D- and 3D-cell culture. BMC Proceedings.7(Suppl 6),P87.
• Pörtner, Ralf; Goepfert, Christiane; Schirmer, Cedric; Hsu, Hao-Hsiang; Blume, Grit; Voigt, Miriam; Rapoport, Daniel Hans, 2016. Reaktionstechnische Charakterisierung von Bioreaktoren für die regenerative Medizin. In: Beckmann, D; Kaufhold, S, Hrsg., 18. Heiligenstädter Kolloquium: Technische Systeme für die Lebenswissenschaften. Heilbad-Heiligenstadt: Institut für Bioprozess- und Analysenmesstechnik e.V. S. 575-582. ISBN: 978-3-00-054165-0.

Other publications

Schirmer, Cedric; Eibl, Dieter, 2018. Shear stress investigations of the magnetically levitated single-use centrifugal pump PuraLev® 600SU using the protein shear stress model for lysozyme, Zurich, Levitronix GmbH.

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