Prof. Dr. Jack Rohrer

ZHAW School of Life Sciences and Facility Management
Fachgruppe Cell physiology and cell engineering
Einsiedlerstrasse 31
8820 Wädenswil

+41 (0) 58 934 57 17
jack.rohrer@zhaw.ch

Projects

A platform enabling efficient and effective delivery and packaging of therapeutic molecules / Project leader / abgeschlossen
Novel cell-based immunization technology and functional validation of resulting antibodies / Project leader / abgeschlossen
Antibody discovery for therapy of pain / Project leader / abgeschlossen

Publications

Articles in scientific journal, peer-reviewed

Sabani, Besmira; Brand, Michael; Albert, Ina; Inderbitzin, Joelle; Eichenseher, Fritz; Schmelcher, Mathias; Rohrer, Jack; Riedl, Rainer; Lehmann, Steffi,

2023.

A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging.

Nanomedicine: Nanotechnology, Biology and Medicine.

47(102607).

Available from: https://doi.org/10.1016/j.nano.2022.102607
Kozono, Takuma; Sato, Hiroyuki; Okumura, Wataru; Jogano, Chifuyu; Tamura-Nakano, Miwa; Kawamura, Yuki I.; Rohrer, Jack; Tonozuka, Takashi; Nishikawa, Atsushi,

2021.

The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.

Scientific Reports.

11(753).

Available from: https://doi.org/10.1038/s41598-020-80258-5
Luginbühl, Vera; Meier, Nicolas; Kovar, Karin; Rohrer, Jack,

2018.

Intracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy.

Biotechnology Advances.

36(3), pp. 613-623.

Available from: https://doi.org/10.1016/j.biotechadv.2018.02.005
Peanne, Romain; Legrand, Dominique; Duvet, Sandrine; Mir, Anne-Marie; Matthijs, Gert; Rohrer, Jack; Foulquier, Francois,

2011.

Differential effects of lobe A and lobe B of the conserved oligomeric golgi complex on the stability of β1,4-galactosyltransferase 1 and α2,6-sialyltransferase 1.

Glycobiology.

21(7), pp. 864-876.

Available from: https://doi.org/10.1093/glycob/cwq176
Schaub, Beat E.; Berger, Eric G.; Rohrer, Jack,

2008.

Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition.

Cellular and Molecular Life Sciences.

65(22), pp. 3677-3687.

Available from: https://doi.org/10.1007/s00018-008-8446-y
Schaub, Beat E.; Berger, Bea; Berger, Eric G.; Rohrer, Jack,

2006.

Transition of galactosyltransferase 1 from trans-golgi cisterna to the trans-golgi network is signal mediated.

Molecular Biology of the Cell.

17(12), pp. 5153-5162.

Available from: https://doi.org/10.1091/mbc.e06-08-0665
Nair, Prashant; Schaub, Beat E.; Huang, Kai; Chen, Xiang; Murphy, Robert F.; Griffith, Janice M.; Geuze, Hans J.; Rohrer, Jack,

2005.

Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.

Journal of Cell Science.

118(13), pp. 2949-2956.

Available from: https://doi.org/10.1242/jcs.02434
Pulipparacharuvil, Suprabha; Akbar, Mohammed; Ray, Sanchali; Sevrioukov, Evgueny A.; Haberman, Adam S.; Rohrer, Jack; Krämer, Helmut,

2005.

Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.

Journal of Cell Science.

118(16), pp. 3663-3673.

Available from: https://doi.org/10.1242/jcs.02502
Müntener, Kathrin; Zwicky, Roman; Csucs, Gabor; Rohrer, Jack; Baici, Antonio,

2004.

Exon skipping of cathepsin B : mitochondrial targeting of a lysosomal peptidase provokes cell death.

Journal of Biological Chemistry.

279(39), pp. 41012-41017.

Available from: https://doi.org/10.1074/jbc.M405333200
Stöckli, Jacqueline; Höning, Stefan; Rohrer, Jack,

2004.

The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.

Journal of Biological Chemistry.

279(22), pp. 23542-23549.

Available from: https://doi.org/10.1074/jbc.M313525200
Stöckli, Jacqueline; Rohrer, Jack,

2004.

The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.

Molecular Biology of the Cell.

15(6), pp. 2617-2626.

Available from: https://doi.org/10.1091/mbc.e03-11-0808
Nair, Prashant; Schaub, Beat E; Rohrer, Jack,

2003.

Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor.

Journal of Biological Chemistry.

278(27), pp. 24753-24758.

Available from: https://doi.org/10.1074/jbc.M300174200
Berger, Eric G.; Rohrer, Jack,

2003.

Galactosyltransferase — still up and running.

Biochimie.

85(3-4), pp. 261-274.

Available from: https://doi.org/10.1016/S0300-9084(03)00008-7
Crottet, Pascal; Meyer, Daniel M.; Rohrer, Jack; Spiess, Martin,

2002.

ARF1.GTP, tyrosine-based signals, and phosphatidylinositol 4,5-bisphosphate constitute a minimal machinery to recruit the AP-1 clathrin adaptor to membranes.

Molecular Biology of the Cell.

13(10), pp. 3672-3682.

Available from: https://doi.org/10.1091/mbc.e02-05-0309
Mathews, Paul M.; Guerra, Carolyn B.; Jiang, Ying; Grbovic, Olivera M.; Kao, Benjamin H.; Schmidt, Stephen D.; Dinakar, Ravi; Mercken, Marc; Hille-Rehfeld, Annette; Rohrer, Jack; Mehta, Pankaj; Cataldo, Anne M.; Nixon, Ralph A.,

2002.

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Aβ secretion : role for altered lysosomal hydrolase distribution in β-amyloidogenesis.

Journal of Biological Chemistry.

277(7), pp. 5299-5307.

Available from: https://doi.org/10.1074/jbc.M108161200
Lee, Wang-Sik; Rohrer, Jack; Kornfeld, Rosalind; Kornfeld, Stuart,

2002.

Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme.

Journal of Biological Chemistry.

277(5), pp. 3544-3551.

Available from: https://doi.org/10.1074/jbc.M108531200
Rohrer, Jack; Kornfeld, Rosalind,

2001.

Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.

Molecular Biology of the Cell.

12(6), pp. 1623-1631.

Available from: https://doi.org/10.1091/mbc.12.6.1623
Schweizer, Anja; Stahl, Philip D.; Rohrer, Jack,

2000.

A di-aromatic motif in the cytosolic tail of the mannose receptor mediates endosomal sorting.

Journal of Biological Chemistry.

275(38), pp. 29694-29700.

Available from: https://doi.org/10.1074/jbc.M000571200
Schweizer, Anja; Valdenaire, Olivier; Köster, Anja; Lang, Yolande; Schmitt, Georg; Lenz, Barbara; Bluethmann, Horst; Rohrer, Jack,

1999.

Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family.

Journal of Biological Chemistry.

274(29), pp. 20450-20456.

Available from: https://doi.org/10.1074/jbc.274.29.20450
Schweizer, Anja; Löffler, Bernd-Michael; Rohrer, Jack,

1999.

Palmitoylation of the three isoforms of human endothelin-converting enzyme-1.

Biochemical Journal.

340(3), pp. 649-656.

Available from: https://doi.org/10.1042/bj3400649
Olayioye, Monilola A.; Graus-Porta, Diana; Beerli, Roger R.; Rohrer, Jack; Gay, Brigitte; Hynes, Nancy E.,

1998.

ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.

Molecular and Cellular Biology.

18(9), pp. 5042-5051.

Available from: https://doi.org/10.1128/MCB.18.9.5042
Schweizer, Anja; Kornfeld, Stuart; Rohrer, Jack,

1997.

Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail.

Proceedings of the National Academy of Sciences of the United States of America.

94(26), pp. 14471-14476.

Available from: https://doi.org/10.1073/pnas.94.26.14471
Hicke, Linda; Zanolari, Bettina; Pypaert, Marc; Rohrer, Jack; Riezman, Howard,

1997.

Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein.

Molecular Biology of the Cell.

8(1), pp. 13-31.

Available from: https://doi.org/10.1091/mbc.8.1.13
Schweizer, Anja; Kornfeld, Stuart; Rohrer, Jack,

1996.

Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting.

Journal of Cell Biology.

132(4), pp. 577-584.

Available from: https://doi.org/10.1083/jcb.132.4.577
Rohrer, Jack; Schweizer, Anja; Russel, David; Kornfeld, Stuart,

1996.

The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.

Journal of Cell Biology.

132(4), pp. 565-576.

Available from: https://doi.org/10.1083/jcb.132.4.565
Rohrer, Jack; Schweizer, Anja; Johnson, Karl F.; Kornfeld, Stuart,

1995.

A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes.

Journal of Cell Biology.

130(6), pp. 1297-1306.

Available from: https://doi.org/10.1083/jcb.130.6.1297
Schweizer, Anja; Rohrer, Jack; Kornfeld, Stuart,

1995.

Determination of the structural requirements for palmitoylation of p63.

Journal of Biological Chemistry.

270(16), pp. 9638-9644.

Available from: https://doi.org/10.1074/jbc.270.16.9638
Schweizer, Anja; Rohrer, Jack; Slot, Jan W.; Geuze, Hans J.; Kornfeld, Stuart,

1995.

Reassessment of the subcellular localization of p63.

Journal of Cell Science.

108, pp. 2477-2485.

Available from: http://jcs.biologists.org/content/108/6/2477
Schweizer, Anja; Rohrer, Jack; Hauri, Hanspeter; Kornfeld, Stuart,

1994.

Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers.

Journal of Cell Biology.

126(1), pp. 25-39.

Available from: https://doi.org/10.1083/jcb.126.1.25
Rohrer, Jack; Bénédetti, Hélène; Zanolari, Bettina; Riezman, Howard,

1993.

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.

Molecular Biology of the Cell.

4(5), pp. 511-521.

Available from: https://doi.org/10.1091/mbc.4.5.511
Schweizer, Anja; Rohrer, Jack; Jenö, Paul; DeMaio, Antonio; Buchman, Timothy G.; Hauri, Hans-Peter,

1993.

A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein.

Journal of Cell Science.

104, pp. 685-694.

Available from: http://jcs.biologists.org/content/104/3/685.short
Raths, Susan; Rohrer, Jack; Crausaz, Fabienne; Riezman, Howard,

1993.

end3 and end4 : two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

Journal of Cell Biology.

120(1), pp. 55-65.

Available from: https://doi.org/10.1083/jcb.120.1.55
Rohrer, Jack; Kuhn, Andreas,

1990.

The function of a leader peptide in translocating charged amino acyl residues across a membrane.

Science.

250(4986), pp. 1418-1421.

Available from: https://doi.org/10.1126/science.2124001
Kuhn, Andreas; Rohrer, Jack; Gallusser, Andreas,

1990.

Bacteriophages M13 and Pf3 tell us how proteins insert into the membrane.

Journal of Structural Biology.

104(1-3), pp. 38-43.

Available from: https://doi.org/10.1016/1047-8477(90)90055-H

Other publications

Rimann, Markus; Mathes, Stephanie; Raghunath, Michael; Rohrer, Jack,

2016.

Zurich university of applied sciences : center for cell biology and tissue engineering [poster].

In:

Roche Symposium, Basel, 2016.
Raghunath, Michael; Rimann, Markus; Mathes, Stephanie; Rohrer, Jack,

2016.

Zurich University of Applied Sciences : center for cell biology and tissue engineering [poster].

In:

Roche Symposium, Basel, 2016.
Schaub, Beat E; Nair, Prashant; Rohrer, Jack,

2005.

Analysis of protein transport to lysosomes.

Current Protocols in Cell Biology.

27(1).

Available from: https://doi.org/10.1002/0471143030.cb1508s27

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