Prof. Dr. Jack Rohrer

Netzwerk

Mitglied in Netzwerken

• Biotechnet
• Linkedin
• Life Sciences Switzerland
• American Society for Cell Biology
• Xing

Projekte

• Bestenförderung von Lernenden / Projektleiter:in / abgeschlossen
• Forschung und Entwicklung Zellphysiologie / Projektleiter:in / abgeschlossen
• A platform enabling efficient and effective delivery and packaging of therapeutic molecules / Projektleiter:in / abgeschlossen
• Novel cell-based immunization technology and functional validation of resulting antibodies / Projektleiter:in / abgeschlossen
• Antibody discovery for therapy of pain / Projektleiter:in / abgeschlossen

Publikationen

• Sabani, Besmira; Brand, Michael; Albert, Ina; Inderbitzin, Joelle; Eichenseher, Fritz; Schmelcher, Mathias; Rohrer, Jack; Riedl, Rainer; Lehmann, Steffi,

  2023.

  A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging.

  Nanomedicine: Nanotechnology, Biology and Medicine.

  47(102607).

  Verfügbar unter: https://doi.org/10.1016/j.nano.2022.102607

• Kozono, Takuma; Sato, Hiroyuki; Okumura, Wataru; Jogano, Chifuyu; Tamura-Nakano, Miwa; Kawamura, Yuki I.; Rohrer, Jack; Tonozuka, Takashi; Nishikawa, Atsushi,

  2021.

  The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.

  Scientific Reports.

  11(753).

  Verfügbar unter: https://doi.org/10.1038/s41598-020-80258-5

• Luginbühl, Vera; Meier, Nicolas; Kovar, Karin; Rohrer, Jack,

  2018.

  Intracellular drug delivery : potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy.

  Biotechnology Advances.

  36(3), S. 613-623.

  Verfügbar unter: https://doi.org/10.1016/j.biotechadv.2018.02.005

• Peanne, Romain; Legrand, Dominique; Duvet, Sandrine; Mir, Anne-Marie; Matthijs, Gert; Rohrer, Jack; Foulquier, Francois,

  2011.

  Differential effects of lobe A and lobe B of the conserved oligomeric golgi complex on the stability of β1,4-galactosyltransferase 1 and α2,6-sialyltransferase 1.

  Glycobiology.

  21(7), S. 864-876.

  Verfügbar unter: https://doi.org/10.1093/glycob/cwq176

• Schaub, Beat E.; Berger, Eric G.; Rohrer, Jack,

  2008.

  Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition.

  Cellular and Molecular Life Sciences.

  65(22), S. 3677-3687.

  Verfügbar unter: https://doi.org/10.1007/s00018-008-8446-y

• Schaub, Beat E.; Berger, Bea; Berger, Eric G.; Rohrer, Jack,

  2006.

  Transition of galactosyltransferase 1 from trans-golgi cisterna to the trans-golgi network is signal mediated.

  Molecular Biology of the Cell.

  17(12), S. 5153-5162.

  Verfügbar unter: https://doi.org/10.1091/mbc.e06-08-0665

• Nair, Prashant; Schaub, Beat E.; Huang, Kai; Chen, Xiang; Murphy, Robert F.; Griffith, Janice M.; Geuze, Hans J.; Rohrer, Jack,

  2005.

  Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.

  Journal of Cell Science.

  118(13), S. 2949-2956.

  Verfügbar unter: https://doi.org/10.1242/jcs.02434

• Pulipparacharuvil, Suprabha; Akbar, Mohammed; Ray, Sanchali; Sevrioukov, Evgueny A.; Haberman, Adam S.; Rohrer, Jack; Krämer, Helmut,

  2005.

  Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.

  Journal of Cell Science.

  118(16), S. 3663-3673.

  Verfügbar unter: https://doi.org/10.1242/jcs.02502

• Müntener, Kathrin; Zwicky, Roman; Csucs, Gabor; Rohrer, Jack; Baici, Antonio,

  2004.

  Exon skipping of cathepsin B : mitochondrial targeting of a lysosomal peptidase provokes cell death.

  Journal of Biological Chemistry.

  279(39), S. 41012-41017.

  Verfügbar unter: https://doi.org/10.1074/jbc.M405333200

• Stöckli, Jacqueline; Höning, Stefan; Rohrer, Jack,

  2004.

  The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.

  Journal of Biological Chemistry.

  279(22), S. 23542-23549.

  Verfügbar unter: https://doi.org/10.1074/jbc.M313525200

• Stöckli, Jacqueline; Rohrer, Jack,

  2004.

  The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.

  Molecular Biology of the Cell.

  15(6), S. 2617-2626.

  Verfügbar unter: https://doi.org/10.1091/mbc.e03-11-0808

• Nair, Prashant; Schaub, Beat E; Rohrer, Jack,

  2003.

  Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor.

  Journal of Biological Chemistry.

  278(27), S. 24753-24758.

  Verfügbar unter: https://doi.org/10.1074/jbc.M300174200

• Berger, Eric G.; Rohrer, Jack,

  2003.

  Galactosyltransferase — still up and running.

  Biochimie.

  85(3-4), S. 261-274.

  Verfügbar unter: https://doi.org/10.1016/S0300-9084(03)00008-7

• Crottet, Pascal; Meyer, Daniel M.; Rohrer, Jack; Spiess, Martin,

  2002.

  ARF1.GTP, tyrosine-based signals, and phosphatidylinositol 4,5-bisphosphate constitute a minimal machinery to recruit the AP-1 clathrin adaptor to membranes.

  Molecular Biology of the Cell.

  13(10), S. 3672-3682.

  Verfügbar unter: https://doi.org/10.1091/mbc.e02-05-0309

• Mathews, Paul M.; Guerra, Carolyn B.; Jiang, Ying; Grbovic, Olivera M.; Kao, Benjamin H.; Schmidt, Stephen D.; Dinakar, Ravi; Mercken, Marc; Hille-Rehfeld, Annette; Rohrer, Jack; Mehta, Pankaj; Cataldo, Anne M.; Nixon, Ralph A.,

  2002.

  Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Aβ secretion : role for altered lysosomal hydrolase distribution in β-amyloidogenesis.

  Journal of Biological Chemistry.

  277(7), S. 5299-5307.

  Verfügbar unter: https://doi.org/10.1074/jbc.M108161200

• Lee, Wang-Sik; Rohrer, Jack; Kornfeld, Rosalind; Kornfeld, Stuart,

  2002.

  Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme.

  Journal of Biological Chemistry.

  277(5), S. 3544-3551.

  Verfügbar unter: https://doi.org/10.1074/jbc.M108531200

• Rohrer, Jack; Kornfeld, Rosalind,

  2001.

  Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.

  Molecular Biology of the Cell.

  12(6), S. 1623-1631.

  Verfügbar unter: https://doi.org/10.1091/mbc.12.6.1623

• Schweizer, Anja; Stahl, Philip D.; Rohrer, Jack,

  2000.

  A di-aromatic motif in the cytosolic tail of the mannose receptor mediates endosomal sorting.

  Journal of Biological Chemistry.

  275(38), S. 29694-29700.

  Verfügbar unter: https://doi.org/10.1074/jbc.M000571200

• Schweizer, Anja; Valdenaire, Olivier; Köster, Anja; Lang, Yolande; Schmitt, Georg; Lenz, Barbara; Bluethmann, Horst; Rohrer, Jack,

  1999.

  Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family.

  Journal of Biological Chemistry.

  274(29), S. 20450-20456.

  Verfügbar unter: https://doi.org/10.1074/jbc.274.29.20450

• Schweizer, Anja; Löffler, Bernd-Michael; Rohrer, Jack,

  1999.

  Palmitoylation of the three isoforms of human endothelin-converting enzyme-1.

  Biochemical Journal.

  340(3), S. 649-656.

  Verfügbar unter: https://doi.org/10.1042/bj3400649

• Olayioye, Monilola A.; Graus-Porta, Diana; Beerli, Roger R.; Rohrer, Jack; Gay, Brigitte; Hynes, Nancy E.,

  1998.

  ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.

  Molecular and Cellular Biology.

  18(9), S. 5042-5051.

  Verfügbar unter: https://doi.org/10.1128/MCB.18.9.5042

• Schweizer, Anja; Kornfeld, Stuart; Rohrer, Jack,

  1997.

  Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail.

  Proceedings of the National Academy of Sciences of the United States of America.

  94(26), S. 14471-14476.

  Verfügbar unter: https://doi.org/10.1073/pnas.94.26.14471

• Hicke, Linda; Zanolari, Bettina; Pypaert, Marc; Rohrer, Jack; Riezman, Howard,

  1997.

  Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein.

  Molecular Biology of the Cell.

  8(1), S. 13-31.

  Verfügbar unter: https://doi.org/10.1091/mbc.8.1.13

• Schweizer, Anja; Kornfeld, Stuart; Rohrer, Jack,

  1996.

  Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting.

  Journal of Cell Biology.

  132(4), S. 577-584.

  Verfügbar unter: https://doi.org/10.1083/jcb.132.4.577

• Rohrer, Jack; Schweizer, Anja; Russel, David; Kornfeld, Stuart,

  1996.

  The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.

  Journal of Cell Biology.

  132(4), S. 565-576.

  Verfügbar unter: https://doi.org/10.1083/jcb.132.4.565

• Rohrer, Jack; Schweizer, Anja; Johnson, Karl F.; Kornfeld, Stuart,

  1995.

  A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes.

  Journal of Cell Biology.

  130(6), S. 1297-1306.

  Verfügbar unter: https://doi.org/10.1083/jcb.130.6.1297

• Schweizer, Anja; Rohrer, Jack; Kornfeld, Stuart,

  1995.

  Determination of the structural requirements for palmitoylation of p63.

  Journal of Biological Chemistry.

  270(16), S. 9638-9644.

  Verfügbar unter: https://doi.org/10.1074/jbc.270.16.9638

• Schweizer, Anja; Rohrer, Jack; Slot, Jan W.; Geuze, Hans J.; Kornfeld, Stuart,

  1995.

  Reassessment of the subcellular localization of p63.

  Journal of Cell Science.

  108, S. 2477-2485.

  Verfügbar unter: http://jcs.biologists.org/content/108/6/2477

• Schweizer, Anja; Rohrer, Jack; Hauri, Hanspeter; Kornfeld, Stuart,

  1994.

  Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers.

  Journal of Cell Biology.

  126(1), S. 25-39.

  Verfügbar unter: https://doi.org/10.1083/jcb.126.1.25

• Rohrer, Jack; Bénédetti, Hélène; Zanolari, Bettina; Riezman, Howard,

  1993.

  Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.

  Molecular Biology of the Cell.

  4(5), S. 511-521.

  Verfügbar unter: https://doi.org/10.1091/mbc.4.5.511

• Schweizer, Anja; Rohrer, Jack; Jenö, Paul; DeMaio, Antonio; Buchman, Timothy G.; Hauri, Hans-Peter,

  1993.

  A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein.

  Journal of Cell Science.

  104, S. 685-694.

  Verfügbar unter: http://jcs.biologists.org/content/104/3/685.short

• Raths, Susan; Rohrer, Jack; Crausaz, Fabienne; Riezman, Howard,

  1993.

  end3 and end4 : two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

  Journal of Cell Biology.

  120(1), S. 55-65.

  Verfügbar unter: https://doi.org/10.1083/jcb.120.1.55

• Rohrer, Jack; Kuhn, Andreas,

  1990.

  The function of a leader peptide in translocating charged amino acyl residues across a membrane.

  Science.

  250(4986), S. 1418-1421.

  Verfügbar unter: https://doi.org/10.1126/science.2124001

• Kuhn, Andreas; Rohrer, Jack; Gallusser, Andreas,

  1990.

  Bacteriophages M13 and Pf3 tell us how proteins insert into the membrane.

  Journal of Structural Biology.

  104(1-3), S. 38-43.

  Verfügbar unter: https://doi.org/10.1016/1047-8477(90)90055-H

• Rimann, Markus; Mathes, Stephanie; Raghunath, Michael; Rohrer, Jack,

  2016.

  Zurich university of applied sciences : center for cell biology and tissue engineering [Poster].

  In:

  Roche Symposium, Basel, 2016.

• Raghunath, Michael; Rimann, Markus; Mathes, Stephanie; Rohrer, Jack,

  2016.

  Zurich University of Applied Sciences : center for cell biology and tissue engineering [Poster].

  In:

  Roche Symposium, Basel, 2016.

• Schaub, Beat E; Nair, Prashant; Rohrer, Jack,

  2005.

  Analysis of protein transport to lysosomes.

  Current Protocols in Cell Biology.

  27(1).

  Verfügbar unter: https://doi.org/10.1002/0471143030.cb1508s27

Zurück