01.07.24

Elucidating the Role of O2 Uncoupling for the Adaptation of Bacterial Biodegradation Reactions Catalyzed by Rieske Oxygenases

Microorganisms exposed to xenobiotics quickly adapt their enzymatic machinery. The evolution of these enzymes enables the degradation of new molecules that are structurally related to the original target substrates.

17.04.24

2024 EFMC Prize to Rebecca Buller

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) awards the 2024 EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Academia to Rebecca Buller.

11.03.24

Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor

In Communications Chemistry we report the evolution of a ketoreductase that catalyzes a key synthesis step - the reduction of the prochiral ketone to the desired (R,R)-trans alcohol intermediate - with high efficiency in an industrial set-up.