Competence Center for Drug Discovery
The Competence Center for Drug Discovery (CC Drug Discovery) is dedicated to the discovery and development of new drugs for innovative therapies against serious diseases.
Translational drug discovery
The Competence Center for Drug Discovery at the ZHAW works on a national and international level with partners from industry and academia to develop new clinical drug candidates. Our mission is to address therapeutic issues in an interdisciplinary environment and to promote the synergy of biological, chemical and medical expertise. Our core competence in medicinal chemistry enables us to work with our partners on a range of indications (e.g. cancer, infectious diseases, metabolic diseases) for the benefit of patients.
2nd edition "Competencies in Drug Discovery"
The second edition of our symposium “Competencies in Drug Discovery”, brought together 160 international experts from industry and academia, providing both experienced scientists and young researchers with the opportunity for fruitful exchanges and discussions on the future of drug discovery.
Sponsors
1st edition "Competencies in Drug Discovery"
In June 2022, the first symposium “Competencies in Drug Discovery" took place at the ZHAW Wädenswil. During the symposium, projects from various therapeutic indications were discussed in an interdisciplinary environment to promote the synergy of biological, chemical and medical competencies.
Sponsors
Competencies
We cover the entire chemistry driven value chain of small molecule and peptide drug discovery:
- Medicinal Chemistry
- Organic Chemistry
- Computer aided drug design
- Natural Products
- Parallel and automated organic synthesis
- Microwave assisted organic synthesis
- NMR binding studies of small molecules
- Cheminformatics
- Recombinant protein production in different expression systems
- Protein characterization
- Microbial and cellular test methods
- Culture Collection of Switzerland (www.ccos.ch)
Projects
Unfortunately, no list of projects can be displayed here at the moment. Until the list is available again, the project search on the ZHAW homepage can be used.
Selected publications
- Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action / M. Brand, L. Wang, S. Agnello, S. Gazzola, F. M. Gall, L. Raguž, M. Kaiser, R. S. Schmidt, A. Ritschl, J. Jelk, A. Hemphill, P. Mäser, P. Bütikofer, M. Adams, R. Riedl, Angew. Chem. Int. Ed. 2021, 60, 15613.
- Drug Design Inspired by Nature: Crystallographic Detection of an Auto‐Tailored Protease Inhibitor Template / F. M. Gall, D. Hohl, D. Frasson, T. Wermelinger, P. R. E. Mittl, M. Sievers, R. Riedl, Angew. Chem. Int. Ed. 2019, 58, 4051.
- A Structural View on Medicinal Chemistry Strategies against Drug Resistance / S. Agnello, M. Brand, M. F. Chellat, S. Gazzola, R. Riedl, Angew. Chem. Int. Ed. 2019, 58, 3300.
- Pseudouridimycin: The First Nucleoside Analogue That Selectively Inhibits Bacterial RNA Polymerase / M. F. Chellat, R. Riedl, Angew. Chem. Int. Ed. 2017, 56, 13184.
- Targeting Antibiotic Resistance / Chellat, Mathieu; Raguž, Luka; Riedl, Rainer - Angew. Chem. Int. Ed. 2016, 55, 6600-6626; Angew.Chem. 2016, 128, 6710–6738.
- Molecular recognition of the catalytic zinc (II) ion in MMP-13: Structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies / Fischer, Thomas; Riedl, Rainer - invited article for the Special Issue "Enzyme-Inhibitor Interaction as Examples of Molecular Recognition" Int. J. Mol. Sci. 2016, 17, 314. Front cover story 3/2016.
- Merging Allosteric and Active Site Binding Motifs: De novo Generation of Target Selectivity and Potency via Natural-Product-Derived Fragments / Lanz, Jan; Riedl, Rainer - ChemMedChem. 2015, 10, 451–454. Front cover story 3/2015.
Complete List of Publications
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Neidhart, Berna; Kowalska, Malwina; Valentin, Jules D. P.; Gall, Flavio; Ren, Qun; Riedl, Rainer; Pot, Simon; Rottmar, Markus,
2021.
Biomacromolecules.
22(2), pp. 629-639.
Available from: https://doi.org/10.1021/acs.biomac.0c01473
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Fischer, Thomas; Riedl, Rainer,
2020.
Challenges with matrix metalloproteinase inhibition and future drug discovery avenues.
Expert Opinion on Drug Discovery.
16(1), pp. 75-88.
Available from: https://doi.org/10.1080/17460441.2020.1819235
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Kalbermatter, David; Shrestha, Neeta; Gall, Flavio; Wyss, Marianne; Riedl, Rainer; Plattet, Philippe; Fotiadis, Dimitrios,
2020.
Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain.
Journal of Structural Biology: X.
4, pp. 100021.
Available from: https://doi.org/10.1016/j.yjsbx.2020.100021
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Lindenmann, Urs; Brand, Michael; Gall, Flavio; Frasson, David; Hunziker, Lukas; Kroslakova, Ivana; Sievers, Martin; Riedl, Rainer,
2020.
Discovery of a class of potent and selective non‐competitive sentrin‐specific protease 1 inhibitors.
ChemMedChem.
15(8), pp. 675-679.
Available from: https://doi.org/10.1002/cmdc.202000067
Team
