Zebrafish larvae for drug screening
Auf einen Blick
- Projektleiter/in : Prof. Dr. Lars Fieseler, Prof. Dr. Steffi Lehmann, Mathias Sigrist
- Stellv. Projektleiter/in : Boris Pasini, Dr. Marjan Veljkovic
- Projektteam : Patrick Erpen, Laila Mara Müller, Nathalie Pfister, Fridolin Tschudi
- Projektstatus : laufend
- Drittmittelgeber : Andere
- Kontaktperson : Steffi Lehmann
Beschreibung
Inthis 3RCC-funded project, we aim to reduce the number of rodents employed forthe screening of novel antimicrobials using a zebrafish larval model ofbacterial infections. We will set up live microscopic imaging readouts tomonitor bacterial spread in zebrafishlarvae and will use the model to screen novel, bacteriophage-derivedantimicrobials regarding efficacy. This will allow to select drug candidatesfor further preclinical development in zebrafish larvae rather than rodents,thereby significantly reducing the number of mice normally used for thispurpose.