Zebrafish larvae for drug screening
Beschreibung
In this 3RCC-funded project, we aim to reduce the number of rodents employed for the screening of novel antimicrobials using a zebrafish larval model of bacterial infections. We will set up live microscopic imaging readouts to monitor bacterial spread in zebrafish larvae and will use the model to screen novel, bacteriophage-derived antimicrobials regarding efficacy. This will allow to select drug candidates for further preclinical development in zebrafish larvae rather than rodents, thereby significantly reducing the number of mice normally used for this purpose.
Eckdaten
Projektleitung
Stellv. Projektleitung
Dr. Marjan Veljkovic, Boris Pasini, Dr. Patrick Hauswirth
Projektteam
Laila Mara Müller, Fridolin Tschudi, Patrick Erpen, Nathalie Pfister
Projektstatus
laufend, gestartet 05/2024
Institut/Zentrum
Institut für Chemie und Biotechnologie (ICBT); Institut für Lebensmittel- und Getränkeinnovation (ILGI); Institut für Umwelt und Natürliche Ressourcen (IUNR)
Drittmittelgeber
Andere
Life Sciences und Facility Management
Einsiedlerstrasse 31
8820 Wädenswil