The genome of cancer cells is often unstable and has an altered DNA repair landscape. For example, certain DNA repair pathways are switched off, while alternative DNA repair pathways are of particular importance. This dependence on specific DNA repair pathways can be exploited in targeted cancer treatment. Our goal is to identify suitable therapeutic targets from the multitude of DNA repair proteins and to develop specific inhibitors.

DNA (e.g., from viruses and pathogens) can be amplified by the polymerase chain reaction (PCR) using a thermostable DNA polymerase and can be detected and quantified with relatively simple means. However, this requires a thermal cycler that allows rapid changes between different temperatures. In developing countries and structurally weak areas, such devices are usually not available, nor are there appropriately trained medical personnel who could operate them. Various isothermal DNA amplification methods have therefore been developed in recent years, through which DNA can be amplified at a constant temperature and with minimal equipment. The aim of our research is to further develop isothermal amplification methods so that they can be used as so-called point-of-care tests to detect pathogens or viruses.