Development of "next-generation" antibody drug conjugates for the treatment of lung cancer and multiple myeloma
Beschreibung
NBE-Therapeutics has developed novel "next-generation" homogeneous antibody drug conjugates (ADC) with proven efficacy in preclinical models of solid tumors, like lung and breast cancer, and hematological tumors, particularly in multiple myeloma. The goal of the project is to generate optimized ADC lead candidates from early candidates which will be guided by a rigorous assessment of the developability profiles of the ADC. It will include the development of advanced analytical assays and will lead to novel and optimized ADC candidates for clinical development.
Eckdaten
Projektleitung
Prof. Dr. Christiane Zaborosch
Stellv. Projektleitung
Romina Dörig, Ramona Stark
Projektteam
Roland Josuran, Angelika Koller, Flavio Mehli
Projektstatus
abgeschlossen, 05/2016 - 08/2018
Institut/Zentrum
Institut für Chemie und Biotechnologie (ICBT)
Drittmittelgeber
Innosuisse